RBMY1F

Protein identityUniProt · HPA

UniProt accession

Q15415

Gene

RBMY1F

Ensembl

ENSG00000169800

Chromosome

Y

Canonical length

496 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

496 residues, UniProt reviewed canonical sequence.

>Q15415|RBMY1F
     1  MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI KDRTSKSRGF AFITFENPAD
    61  AKNAAKDMNG TSLHGKAIKV EQAKKPSFQS GGRRRPPASS RNRSPSGSLR SARGSSGGTR
   121  GWLPSHEGHL DDGGYTPDLK MSYSRGLIPV KRGPSSRSGG PPPKKSAPSA VARSNSWMGS
   181  QGPMSQRREN YGVPPRRATI SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY
   241  RDNGHSNRDE HSSRGYRNHR SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNHRSSR
   301  ETREYAPPSR GHGYRDYGHS RRHESYSRGY RNHPSSRETR DYAPPHRDYA YRDYGHSSWD
   361  EHSSRGYSYH DGYGEALGRD HSEHLSGSSY RDALQRYGTS HGAPPARGPR MSYGGSTCHA
   421  YSNTRDRYGR SWESYSSCGD FHYCDREHVC RKDQRNPPSL GRVLPDPREA YGSSSYVASI
   481  VDGGESRSEK GDSSRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBMY1F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.66

Highest tissue expression

3 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.88

gnomAD pLI

0.3

gnomAD missense Z

0.52

OntologyGO

Biological processes

• mRNA processing
• positive regulation of mRNA splicing, via spliceosome
• RNA splicing

Molecular functions

• identical protein binding
• RNA binding

Cellular components

• nucleolus
• nucleoplasm
• spliceosomal complex

Protein domainsUniProt · Pfam · InterPro

• RNA recognition motif domain
• RBM1CTR
• Nucleotide-binding alpha-beta plait domain superfamily
• RNA-binding domain superfamily
• RNA-binding motif
• RNA recognition motif
• RBM1CTR (NUC064) family

KeywordsUniProt

• mRNA processing
• mRNA splicing
• Nucleus
• RNA-binding

InteractionsUniProt · HPA

Protein binding partners of RBMY1F in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• KHDRBS3