Seroatlas · Human Serome Atlas

RBM38

RNA-binding protein 38

Also known as: dJ800J21.2, HSRNASEB, RBM38_HUMAN, RNPC1, seb4B, SEB4D

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0Z9
Gene: RBM38
Ensembl: ENSG00000132819
Chromosome: 20
Canonical length: 239 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables mRNA 3'-UTR binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of cell population proliferation; and regulation of gene expression. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

239 residues, UniProt reviewed canonical sequence.

>Q9H0Z9|RBM38
     1  MLLQPAPCAP SAGFPRPLAA PGAMHGSQKD TTFTKIFVGG LPYHTTDASL RKYFEGFGDI
    61  EEAVVITDRQ TGKSRGYGFV TMADRAAAER ACKDPNPIID GRKANVNLAY LGAKPRSLQT
   121  GFAIGVQQLH PTLIQRTYGL TPHYIYPPAI VQPSVVIPAA PVPSLSSPYI EYTPASPAYA
   181  QYPPATYDQY PYAASPATAA SFVGYSYPAA VPQALSAAAP AGTTFVQYQA PQLQPDRMQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 261 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 261 nTPM
bone marrow: 252 nTPM
colon: 86 nTPM
lymph node: 65 nTPM
heart muscle: 64 nTPM
spleen: 58 nTPM

Single-cell type

erythrocytes: 427 nCPM
platelets: 331 nCPM
megakaryocytes: 235 nCPM
pdcs: 139 nCPM
fallopian tube ciliated cells: 117 nCPM
nk-cells: 90 nCPM

Immune cell

T-reg: 15 nTPM
naive B-cell: 11 nTPM
naive CD8 T-cell: 10 nTPM
memory B-cell: 10 nTPM
naive CD4 T-cell: 10 nTPM
gdT-cell: 9.5 nTPM

Brain region

choroid plexus: 46 nTPM
cerebellum: 40 nTPM
midbrain: 34 nTPM
thalamus: 31 nTPM
white matter: 30 nTPM
basal ganglia: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0.72
gnomAD missense Z: 1.03
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM38 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RBM24

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM38 as an antibody target. Whether an autoantibody or antibody against RBM38 could matter depends on whether native RBM38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM38 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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