RBM41
RNA-binding protein 41
Also known as: FLJ11016, RBM41_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96IZ5
- Gene
- RBM41
- Ensembl
- ENSG00000089682
- Chromosome
- X
- Canonical length
- 413 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nuclear speckles,Cytosol
OverviewNCBI Gene
Predicted to enable U12 snRNA binding activity and pre-mRNA intronic binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U12-type spliceosomal complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
413 residues, UniProt reviewed canonical sequence.
>Q96IZ5|RBM41
1 MKRVNSCVKS DEHVLEELET EGERQLKSLL QHQLDTSVSI EECMSKKESF APGTMYKPFG
61 KEAAGTMTLS QFQTLHEKDQ ETASLRELGL NETEILIWKS HVSGEKKTKL RATPEAIQNR
121 LQDIEERISE RQRILCLPQR FAKSKQLTRR EMEIEKSLFQ GADRHSFLKA LYYQDEPQKK
181 NKGDPMNNLE SFYQEMIMKK RLEEFQLMRG EPFASHSLVS ATSVGDSGTA ESPSLLQDKG
241 KQAAQGKGPS LHVANVIDFS PEQCWTGPKK LTQPIEFVPE DEIQRNRLSE EEIRKIPMFS
301 SYNPGEPNKV LYLKNLSPRV TERDLVSLFA RFQEKKGPPI QFRMMTGRMR GQAFITFPNK
361 EIAWQALHLV NGYKLHGKIL VIEFGKNKKQ RSNLQATSLI SCATGSTTEI SGSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RBM41 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 9.1 nTPM
Expression across tissuesHPA
Tissue
- parathyroid gland: 9.1 nTPM
- liver: 8.1 nTPM
- duodenum: 7.5 nTPM
- tongue: 7.5 nTPM
- thymus: 6.7 nTPM
- kidney: 6.6 nTPM
Single-cell type
- sertoli cells: 343 nCPM
- adrenal cortex cells: 123 nCPM
- choroid plexus epithelial cells: 117 nCPM
- endometrial ciliated cells: 101 nCPM
- renal connecting tubule cells: 94 nCPM
- myonuclei: 87 nCPM
Immune cell
- basophil: 11 nTPM
- eosinophil: 8.5 nTPM
- NK-cell: 6.8 nTPM
- classical monocyte: 5.3 nTPM
- memory B-cell: 5.3 nTPM
- memory CD8 T-cell: 4.7 nTPM
Brain region
- cerebellum: 16 nTPM
- choroid plexus: 15 nTPM
- medulla oblongata: 13 nTPM
- white matter: 12 nTPM
- cerebral cortex: 12 nTPM
- midbrain: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.32
- gnomAD pLI
- 0.97
- gnomAD missense Z
- 0.68
- DepMap mean gene effect
- 0.18
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- via spliceosome
- mRNA splicing
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RBM41 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RBM41 as an antibody target. Whether an autoantibody or antibody against RBM41 could matter depends on whether native RBM41 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RBM41 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RBM41 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...