Seroatlas · Human Serome Atlas

CPEB4

Cytoplasmic polyadenylation element-binding protein 4

Also known as: CPEB4_HUMAN, KIAA1673

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q17RY0
Gene: CPEB4
Ensembl: ENSG00000113742
Chromosome: 5
Canonical length: 729 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; negative regulation of cytoplasmic translation; and response to ischemia. Located in cytoplasm and nucleus. Biomarker of liver cirrhosis; portal hypertension; and primary biliary cholangitis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

729 residues, UniProt reviewed canonical sequence.

>Q17RY0|CPEB4
     1  MGDYGFGVLV QSNTGNKSAF PVRFHPHLQP PHHHQNATPS PAAFINNNTA ANGSSAGSAW
    61  LFPAPATHNI QDEILGSEKA KSQQQEQQDP LEKQQLSPSP GQEAGILPET EKAKSEENQG
   121  DNSSENGNGK EKIRIESPVL TGFDYQEATG LGTSTQPLTS SASSLTGFSN WSAAIAPSSS
   181  TIINEDASFF HQGGVPAASA NNGALLFQNF PHHVSPGFGG SFSPQIGPLS QHHPHHPHFQ
   241  HHHSQHQQQR RSPASPHPPP FTHRNAAFNQ LPHLANNLNK PPSPWSSYQS PSPTPSSSWS
   301  PGGGGYGGWG GSQGRDHRRG LNGGITPLNS ISPLKKNFAS NHIQLQKYAR PSSAFAPKSW
   361  MEDSLNRADN IFPFPDRPRT FDMHSLESSL IDIMRAENDT IKGRLNYSYP GSDSSLLINA
   421  RTYGRRRGQS SLFPMEDGFL DDGRGDQPLH SGLGSPHCFS HQNGERVERY SRKVFVGGLP
   481  PDIDEDEITA SFRRFGPLIV DWPHKAESKS YFPPKGYAFL LFQDESSVQA LIDACIEEDG
   541  KLYLCVSSPT IKDKPVQIRP WNLSDSDFVM DGSQPLDPRK TIFVGGVPRP LRAVELAMIM
   601  DRLYGGVCYA GIDTDPELKY PKGAGRVAFS NQQSYIAAIS ARFVQLQHGE IDKRVEVKPY
   661  VLDDQLCDEC QGARCGGKFA PFFCANVTCL QYYCEYCWAA IHSRAGREFH KPLVKEGGDR
   721  PRHISFRWN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPEB4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

liver: 74 nTPM
parathyroid gland: 69 nTPM
bone marrow: 68 nTPM
adrenal gland: 62 nTPM
skeletal muscle: 59 nTPM
tongue: 58 nTPM

Single-cell type

distal convoluted tubule cells: 1,600 nCPM
adrenal cortex cells: 1,334 nCPM
neutrophils: 1,243 nCPM
choroid plexus epithelial cells: 891 nCPM
podocytes: 757 nCPM
platelets: 649 nCPM

Immune cell

neutrophil: 5.7 nTPM
non-classical monocyte: 1.5 nTPM
eosinophil: 1.2 nTPM
memory B-cell: 1.2 nTPM
classical monocyte: 1.1 nTPM
intermediate monocyte: 1.1 nTPM

Brain region

choroid plexus: 165 nTPM
cerebellum: 163 nTPM
white matter: 136 nTPM
cerebral cortex: 131 nTPM
basal ganglia: 129 nTPM
midbrain: 128 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.99
gnomAD missense Z: 3.31
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CPEB4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TOB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPEB4 as an antibody target. Whether an autoantibody or antibody against CPEB4 could matter depends on whether native CPEB4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPEB4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CPEB4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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