Seroatlas · Human Serome Atlas

MSI2

RNA-binding protein Musashi homolog 2

Also known as: MSI2H_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96DH6
Gene
MSI2
Ensembl
ENSG00000153944
Chromosome
17
Canonical length
328 aa
Protein class
Cancer-related genes, Disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

328 residues, UniProt reviewed canonical sequence.

>Q96DH6|MSI2
     1  MEANGSQGTS GSANDSQHDP GKMFIGGLSW QTSPDSLRDY FSKFGEIREC MVMRDPTTKR
    61  SRGFGFVTFA DPASVDKVLG QPHHELDSKT IDPKVAFPRR AQPKMVTRTK KIFVGGLSAN
   121  TVVEDVKQYF EQFGKVEDAM LMFDKTTNRH RGFGFVTFEN EDVVEKVCEI HFHEINNKMV
   181  ECKKAQPKEV MFPPGTRGRA RGLPYTMDAF MLGMGMLGYP NFVATYGRGY PGFAPSYGYQ
   241  FPGFPAAAYG PVAAAAVAAA RGSGSNPARP GGFPGANSPG PVADLYGPAS QDSGVGNYIS
   301  AASPQPGSGF GHGIAGPLIA TAFTNGYH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
117 nTPM

Expression across tissuesHPA

Tissue

  • retina: 117 nTPM
  • parathyroid gland: 83 nTPM
  • adrenal gland: 65 nTPM
  • skeletal muscle: 57 nTPM
  • pituitary gland: 50 nTPM
  • choroid plexus: 50 nTPM

Single-cell type

  • pituicytes/fscs: 2,837 nCPM
  • choroid plexus epithelial cells: 2,522 nCPM
  • hematopoietic stem cells: 2,363 nCPM
  • rod photoreceptor cells: 1,742 nCPM
  • cone photoreceptor cells: 1,642 nCPM
  • ependymal cells: 1,617 nCPM

Immune cell

  • basophil: 2.7 nTPM
  • eosinophil: 1.9 nTPM
  • T-reg: 1.6 nTPM
  • plasmacytoid DC: 1.1 nTPM
  • memory CD4 T-cell: 0.8 nTPM
  • NK-cell: 0.8 nTPM

Brain region

  • choroid plexus: 229 nTPM
  • midbrain: 197 nTPM
  • medulla oblongata: 183 nTPM
  • hypothalamus: 166 nTPM
  • spinal cord: 142 nTPM
  • thalamus: 132 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
0.99
gnomAD missense Z
2.29
DepMap mean gene effect
-0.2
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MSI2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSI2 as an antibody target. Whether an autoantibody or antibody against MSI2 could matter depends on whether native MSI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSI2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MSI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MSI2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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