Seroatlas · Human Serome Atlas

PSPC1

Paraspeckle component 1

Also known as: FLJ10955, PSP1, PSPC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WXF1
Gene
PSPC1
Ensembl
ENSG00000121390
Chromosome
13
Canonical length
523 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

523 residues, UniProt reviewed canonical sequence.

>Q8WXF1|PSPC1
     1  MMLRGNLKQV RIEKNPARLR ALESAVGESE PAAAAAMALA LAGEPAPPAP APPEDHPDEE
    61  MGFTIDIKSF LKPGEKTYTQ RCRLFVGNLP TDITEEDFKR LFERYGEPSE VFINRDRGFG
   121  FIRLESRTLA EIAKAELDGT ILKSRPLRIR FATHGAALTV KNLSPVVSNE LLEQAFSQFG
   181  PVEKAVVVVD DRGRATGKGF VEFAAKPPAR KALERCGDGA FLLTTTPRPV IVEPMEQFDD
   241  EDGLPEKLMQ KTQQYHKERE QPPRFAQPGT FEFEYASRWK ALDEMEKQQR EQVDRNIREA
   301  KEKLEAEMEA ARHEHQLMLM RQDLMRRQEE LRRLEELRNQ ELQKRKQIQL RHEEEHRRRE
   361  EEMIRHREQE ELRRQQEGFK PNYMENREQE MRMGDMGPRG AINMGDAFSP APAGNQGPPP
   421  MMGMNMNNRA TIPGPPMGPG PAMGPEGAAN MGTPMMPDNG AVHNDRFPQG PPSQMGSPMG
   481  SRTGSETPQA PMSGVGPVSG GPGGFGRGSQ GGNFEGPNKR RRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSPC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 51 nTPM
  • testis: 23 nTPM
  • thymus: 22 nTPM
  • epididymis: 21 nTPM
  • tonsil: 21 nTPM
  • skeletal muscle: 20 nTPM

Single-cell type

  • neutrophils: 340 nCPM
  • neutrophil progenitors: 309 nCPM
  • rod photoreceptor cells: 277 nCPM
  • extravillous trophoblasts: 267 nCPM
  • pituicytes/fscs: 238 nCPM
  • thyrotrophs: 221 nCPM

Immune cell

  • memory B-cell: 23 nTPM
  • intermediate monocyte: 23 nTPM
  • naive B-cell: 23 nTPM
  • T-reg: 22 nTPM
  • classical monocyte: 21 nTPM
  • plasmacytoid DC: 21 nTPM

Brain region

  • white matter: 40 nTPM
  • cerebral cortex: 36 nTPM
  • cerebellum: 34 nTPM
  • medulla oblongata: 33 nTPM
  • basal ganglia: 31 nTPM
  • hypothalamus: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.99
gnomAD missense Z
2.53
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSPC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSPC1 as an antibody target. Whether an autoantibody or antibody against PSPC1 could matter depends on whether native PSPC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSPC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSPC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSPC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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