Seroatlas · Human Serome Atlas

RBMXL3

RNA-binding motif protein, X-linked-like-3

Also known as: CXorf55, FLJ40249, RMXL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7X1
Gene: RBMXL3
Ensembl: ENSG00000175718
Chromosome: X
Canonical length: 1067 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable mRNA binding activity and snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1067 residues, UniProt reviewed canonical sequence.

>Q8N7X1|RBMXL3
     1  MMEADRPEKL FIGGLNLKTD EKALKAEFGK YGHIIKVFLM KDRKTNKSRG FAFVTFESPA
    61  DAKAAARDMN GKYLDGKAIM VAQTIKPAFK SSRWVPPTPG SGSRSRFSHR TRGGGSSPQR
   121  PPSQGRPDDG RGYAGYFDLW PYRAPMPRKR GPPPRHWASP PHKRATPSSL AHSVGCGMRG
   181  KAPTVSGQDG YSGLQPRRWA GPPHKRAVPR SSLARIGGSG MPGKAPAVWG QDGYSGPRVR
   241  EPLPPCRDPG DFVPALRDYS RRYYGHSSVP DYRPLRGDGN QNGYRGRDHE YTDHPSKGSY
   301  REPLKSYGGP CGAAPVWGTP PSYGGGCRYE EYQGNSPDAC SEGRSSEALP VVLPDAYSRD
   361  HSPKAYSGGR SSSSNGYSRS DRYGEEGCYE EYRGRSPDAH SGGRNSSSNS YGQSHHYGGE
   421  GRYEEYRGRS HEARSGGRST DAHSRGRSDD AYSGGHDSSS WSDCCGGGGR YEEYQGRSLD
   481  ANSGGCSPEA YSGGHDNSSW SDRYGVGGHY EENRGHSLDA NSGGRSPDTH SGGHSSSSNS
   541  YGQSHRYGGE GRYEYRGRSH DAHSGGCSAD AYSGGHDSSS QSNRYGGGGC YEEYRGRSLD
   601  ANSGGRSPNA YSGGHDSSSW SHRYGGGGRY EEYRGRSLDA NSGGRSPDAY SGGHDSSGQS
   661  NCYGGGGRYE EYRGRLLDAN SGGRSPDAYS GGHDSSSQSN RYGGGGRYEE YRGHSLDANS
   721  GGRSPDTYSR GHDSSSQSDH YGGGGRSLDA NSSGRLPDAY SGGHDSSSRS HRYGGGGRYE
   781  EYRGRSLDAN SGGRSPNAYS GGHNSSSRND PCRGGGRYEE NRGHSLDANS GGHSPNAYSG
   841  GRDSSSNSYD RSHRYGGGGH YEEYRGRSHD THSRGRSPDA HSGDHYTEAY SRGRDSFSNS
   901  YGRSDHYGRG GCYEEYQGRS PNAYGGGRGL NSSNNSHGRS HRYGGGGRYE EYRGPSPDAH
   961  SGGRDSSIKS YGLSDRYGGG GHYEEYQGSL PDAYSGDHDR SSNSYGRSDR YSRGRDRVGR
  1021  PDRGLPLPME TGSPPLHDSY SRSGCRVPRG GGRQGGRFER GEGRSRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBMXL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 2.6 nTPM

Expression across tissuesHPA

Tissue

testis: 2.6 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early primary spermatocytes: 26 nCPM
differentiating spermatogonia: 16 nCPM
undifferentiated spermatogonia: 5.3 nCPM
epicardial cells: 2.3 nCPM
late spermatids: 0.7 nCPM
hematopoietic stem cells: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 1.4 nTPM
white matter: 1.2 nTPM
cerebral cortex: 1 nTPM
medulla oblongata: 1 nTPM
basal ganglia: 0.9 nTPM
pons: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.84
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

via spliceosome
mRNA splicing

Molecular functions

Cellular components

organelle

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBMXL3 as an antibody target. Whether an autoantibody or antibody against RBMXL3 could matter depends on whether native RBMXL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBMXL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBMXL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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