Seroatlas · Human Serome Atlas

RBM6

RNA-binding protein 6

Also known as: 3G2, DEF-3, DEF3, g16, NY-LU-12, RBM6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P78332
Gene: RBM6
Ensembl: ENSG00000004534
Chromosome: 3
Canonical length: 1123 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytoplasmic bodies

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1123 residues, UniProt reviewed canonical sequence.

>P78332|RBM6
     1  MWGDSRPANR TGPFRGSQEE RFAPGWNRDY PPPPLKSHAQ ERHSGNFPGR DSLPFDFQGH
    61  SGPPFANVEE HSFSYGARDG PHGDYRGGEG PGHDFRGGDF SSSDFQSRDS SQLDFRGRDI
   121  HSGDFRDREG PPMDYRGGDG TSMDYRGREA PHMNYRDRDA HAVDFRGRDA PPSDFRGRGT
   181  YDLDFRGRDG SHADFRGRDL SDLDFRAREQ SRSDFRNRDV SDLDFRDKDG TQVDFRGRGS
   241  GTTDLDFRDR DTPHSDFRGR HRSRTDQDFR GREMGSCMEF KDREMPPVDP NILDYIQPST
   301  QDREHSGMNV NRREESTHDH TIERPAFGIQ KGEFEHSETR EGETQGVAFE HESPADFQNS
   361  QSPVQDQDKS QLSGREEQSS DAGLFKEEGG LDFLGRQDTD YRSMEYRDVD HRLPGSQMFG
   421  YGQSKSFPEG KTARDAQRDL QDQDYRTGPS EEKPSRLIRL SGVPEDATKE EILNAFRTPD
   481  GMPVKNLQLK EYNTGYDYGY VCVEFSLLED AIGCMEANQG TLMIQDKEVT LEYVSSLDFW
   541  YCKRCKANIG GHRSSCSFCK NPREVTEAKQ ELITYPQPQK TSIPAPLEKQ PNQPLRPADK
   601  EPEPRKREEG QESRLGHQKR EAERYLPPSR REGPTFRRDR ERESWSGETR QDGESKTIML
   661  KRIYRSTPPE VIVEVLEPYV RLTTANVRII KNRTGPMGHT YGFIDLDSHA EALRVVKILQ
   721  NLDPPFSIDG KMVAVNLATG KRRNDSGDHS DHMHYYQGKK YFRDRRGGGR NSDWSSDTNR
   781  QGQQSSSDCY IYDSATGYYY DPLAGTYYDP NTQQEVYVPQ DPGLPEEEEI KEKKPTSQGK
   841  SSSKKEMSKR DGKEKKDRGV TRFQENASEG KAPAEDVFKK PLPPTVKKEE SPPPPKVVNP
   901  LIGLLGEYGG DSDYEEEEEE EQTPPPQPRT AQPQKREEQT KKENEEDKLT DWNKLACLLC
   961  RRQFPNKEVL IKHQQLSDLH KQNLEIHRKI KQSEQELAYL ERREREGKFK GRGNDRREKL
  1021  QSFDSPERKR IKYSRETDSD RKLVDKEDID TSSKGGCVQQ ATGWRKGTGL GYGHPGLASS
  1081  EEAEGRMRGP SVGASGRTSK RQSNETYRDA VRRVMFARYK ELD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 109 nTPM

Expression across tissuesHPA

Tissue

spleen: 109 nTPM
cervix: 104 nTPM
prostate: 101 nTPM
ovary: 101 nTPM
pancreas: 95 nTPM
kidney: 90 nTPM

Single-cell type

cardiomyocytes: 701 nCPM
epicardial cells: 630 nCPM
sertoli cells: 611 nCPM
adipocytes: 593 nCPM
myonuclei: 555 nCPM
proximal tubule cells: 490 nCPM

Immune cell

basophil: 17 nTPM
gdT-cell: 13 nTPM
memory B-cell: 12 nTPM
naive B-cell: 12 nTPM
MAIT T-cell: 11 nTPM
naive CD8 T-cell: 10 nTPM

Brain region

cerebral cortex: 51 nTPM
cerebellum: 51 nTPM
hypothalamus: 46 nTPM
medulla oblongata: 44 nTPM
choroid plexus: 43 nTPM
thalamus: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.14
gnomAD pLI: 1
gnomAD missense Z: 2.17
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

G-patch domain
RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
OCRE domain
G-patch domain
OCRE domain
RBM6, RNA recognition motif 1
RBM6, RNA recognition motif 2
RBM6, OCRE domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM6 as an antibody target. Whether an autoantibody or antibody against RBM6 could matter depends on whether native RBM6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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