Seroatlas · Human Serome Atlas

MYEF2

Myelin expression factor 2

Also known as: MYEF2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2K5
Gene: MYEF2
Canonical length: 600 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for MYEF2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

600 residues, UniProt reviewed canonical sequence.

>Q9P2K5|MYEF2
     1  MADANKAEVP GATGGDSPHL QPAEPPGEPR REPHPAEAEK QQPQHSSSSN GVKMENDESA
    61  KEEKSDLKEK STGSKKANRF HPYSKDKNSG AGEKKGPNRN RVFISNIPYD MKWQAIKDLM
   121  REKVGEVTYV ELFKDAEGKS RGCGVVEFKD EEFVKKALET MNKYDLSGRP LNIKEDPDGE
   181  NARRALQRTG GSFPGGHVPD MGSGLMNLPP SILNNPNIPP EVISNLQAGR LGSTIFVANL
   241  DFKVGWKKLK EVFSIAGTVK RADIKEDKDG KSRGMGTVTF EQAIEAVQAI SMFNGQFLFD
   301  RPMHVKMDDK SVPHEEYRSH DGKTPQLPRG LGGIGMGLGP GGQPISASQL NIGGVMGNLG
   361  PGGMGMDGPG FGGMNRIGGG IGFGGLEAMN SMGGFGGVGR MGELYRGAMT SSMERDFGRG
   421  DIGINQGFGD SFGRLGSAMI GGFAGRIGSS NMGPVGSGIS GGMGSMNSVT GGMGMGLDRM
   481  SSSFDRMGPG IGAILERSID MDRGFLSGPM GSGMRERIGS KGNQIFVRNL PFDLTWQKLK
   541  EKFSQCGHVM FAEIKMENGK SKGCGTVRFD SPESAEKACR IMNGIKISGR EIDVRLDRNA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYEF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

retina: 31 nTPM
spinal cord: 28 nTPM
testis: 26 nTPM
cerebral cortex: 26 nTPM
midbrain: 25 nTPM
cerebellum: 24 nTPM

Single-cell type

lactotrophs: 375 nCPM
thyrotrophs: 327 nCPM
somatotrophs: 287 nCPM
pituicytes/fscs: 277 nCPM
corticotrophs: 229 nCPM
gonadotrophs: 219 nCPM

Immune cell

NK-cell: 0.4 nTPM
memory B-cell: 0.3 nTPM
myeloid DC: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
T-reg: 0.2 nTPM

Brain region

cerebellum: 50 nTPM
cerebral cortex: 41 nTPM
hypothalamus: 40 nTPM
white matter: 39 nTPM
thalamus: 33 nTPM
basal ganglia: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.63
gnomAD missense Z: 1.53
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
RRT5/SRSF/Splicing Factor SR
RNA recognition motif
MEF-2, RNA recognition motif 1
MEF-2, RNA recognition motif 3

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYEF2 as an antibody target. Whether an autoantibody or antibody against MYEF2 could matter depends on whether native MYEF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYEF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYEF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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