Seroatlas · Human Serome Atlas

RBM22

Pre-mRNA-splicing factor RBM22

Also known as: Cwc2, FLJ10290, fSAP47, RBM22_HUMAN, ZC3H16

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NW64
Gene
RBM22
Ensembl
ENSG00000086589
Chromosome
5
Canonical length
420 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

420 residues, UniProt reviewed canonical sequence.

>Q9NW64|RBM22
     1  MATSLGSNTY NRQNWEDADF PILCQTCLGE NPYIRMTKEK YGKECKICAR PFTVFRWCPG
    61  VRMRFKKTEV CQTCSKLKNV CQTCLLDLEY GLPIQVRDAG LSFKDDMPKS DVNKEYYTQN
   121  MEREISNSDG TRPVGMLGKA TSTSDMLLKL ARTTPYYKRN RPHICSFWVK GECKRGEECP
   181  YRHEKPTDPD DPLADQNIKD RYYGINDPVA DKLLKRASTM PRLDPPEDKT ITTLYVGGLG
   241  DTITETDLRN HFYQFGEIRT ITVVQRQQCA FIQFATRQAA EVAAEKSFNK LIVNGRRLNV
   301  KWGRSQAARG KEKEKDGTTD SGIKLEPVPG LPGALPPPPA AEEEASANYF NLPPSGPPAV
   361  VNIALPPPPG IAPPPPPGFG PHMFHPMGPP PPFMRAPGPI HYPSQDPQRM GAHAGKHSSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
61 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 61 nTPM
  • thymus: 39 nTPM
  • tongue: 32 nTPM
  • ovary: 31 nTPM
  • tonsil: 30 nTPM
  • lymph node: 27 nTPM

Single-cell type

  • neutrophils: 127 nCPM
  • endometrial luminal cells: 96 nCPM
  • endometrial glandular cells: 96 nCPM
  • endometrial secretory cells: 92 nCPM
  • syncytiotrophoblasts: 91 nCPM
  • cytotrophoblasts: 64 nCPM

Immune cell

  • neutrophil: 53 nTPM
  • eosinophil: 52 nTPM
  • non-classical monocyte: 47 nTPM
  • NK-cell: 44 nTPM
  • MAIT T-cell: 38 nTPM
  • memory B-cell: 38 nTPM

Brain region

  • white matter: 40 nTPM
  • cerebral cortex: 34 nTPM
  • cerebellum: 33 nTPM
  • medulla oblongata: 32 nTPM
  • basal ganglia: 31 nTPM
  • spinal cord: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.14
gnomAD pLI
1
gnomAD missense Z
3.16
DepMap mean gene effect
-1.7
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM22 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM22 as an antibody target. Whether an autoantibody or antibody against RBM22 could matter depends on whether native RBM22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RBM22. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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