Seroatlas · Human Serome Atlas

CIRBP

Cold-inducible RNA-binding protein

Also known as: CIRBP_HUMAN, CIRP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14011
Gene: CIRBP
Ensembl: ENSG00000099622
Chromosome: 19
Canonical length: 172 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables mRNA 3'-UTR binding activity and small ribosomal subunit rRNA binding activity. Involved in mRNA stabilization; positive regulation of translation; and response to UV. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

172 residues, UniProt reviewed canonical sequence.

>Q14011|CIRBP
     1  MASDEGKLFV GGLSFDTNEQ SLEQVFSKYG QISEVVVVKD RETQRSRGFG FVTFENIDDA
    61  KDAMMAMNGK SVDGRQIRVD QAGKSSDNRS RGYRGGSAGG RGFFRGGRGR GRGFSRGGGD
   121  RGYGGNRFES RSGGYGGSRD YYSSRSQSGG YSDRSSGGSY RDSYDSYATH NE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIRBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 736 nTPM

Expression across tissuesHPA

Tissue

ovary: 736 nTPM
pancreas: 571 nTPM
fallopian tube: 467 nTPM
parathyroid gland: 461 nTPM
pituitary gland: 461 nTPM
cervix: 460 nTPM

Single-cell type

ovarian stromal cells: 1,207 nCPM
epididymal principal cells: 1,106 nCPM
epididymal basal cells: 1,057 nCPM
decidual stromal cells: 949 nCPM
epididymal clear cells: 923 nCPM
gastric chief cells: 911 nCPM

Immune cell

plasmacytoid DC: 273 nTPM
naive B-cell: 269 nTPM
memory B-cell: 250 nTPM
T-reg: 245 nTPM
non-classical monocyte: 238 nTPM
NK-cell: 230 nTPM

Brain region

hypothalamus: 245 nTPM
white matter: 222 nTPM
amygdala: 212 nTPM
cerebellum: 212 nTPM
basal ganglia: 209 nTPM
cerebral cortex: 203 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.34
gnomAD missense Z: 0.84
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CIRBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CIRBP as an antibody target. Whether an autoantibody or antibody against CIRBP could matter depends on whether native CIRBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CIRBP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CIRBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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