Seroatlas · Human Serome Atlas

HNRNPD

Heterogeneous nuclear ribonucleoprotein D0

Also known as: AUF1, HNRPD, HNRPD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14103
Gene: HNRNPD
Ensembl: ENSG00000138668
Chromosome: 4
Canonical length: 355 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

355 residues, UniProt reviewed canonical sequence.

>Q14103|HNRNPD
     1  MSEEQFGGDG AAAAATAAVG GSAGEQEGAM VAATQGAAAA AGSGAGTGGG TASGGTEGGS
    61  AESEGAKIDA SKNEEDEGHS NSSPRHSEAA TAQREEWKMF IGGLSWDTTK KDLKDYFSKF
   121  GEVVDCTLKL DPITGRSRGF GFVLFKESES VDKVMDQKEH KLNGKVIDPK RAKAMKTKEP
   181  VKKIFVGGLS PDTPEEKIRE YFGGFGEVES IELPMDNKTN KRRGFCFITF KEEEPVKKIM
   241  EKKYHNVGLS KCEIKVAMSK EQYQQQQQWG SRGGFAGRAR GRGGGPSQNW NQGYSNYWNQ
   301  GYGNYGYNSQ GYGGYGGYDY TGYNNYYGYG DYSNQQSGYG KVSRRGGHQN SYKPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HNRNPD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 339 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 339 nTPM
thymus: 305 nTPM
tonsil: 275 nTPM
lymph node: 261 nTPM
appendix: 190 nTPM
ovary: 172 nTPM

Single-cell type

erythrocyte progenitors: 520 nCPM
megakaryocyte progenitors: 483 nCPM
monocyte progenitors: 483 nCPM
migrating cytotrophoblasts: 426 nCPM
extravillous trophoblasts: 415 nCPM
neutrophil progenitors: 400 nCPM

Immune cell

plasmacytoid DC: 30 nTPM
basophil: 29 nTPM
T-reg: 23 nTPM
memory B-cell: 22 nTPM
naive CD4 T-cell: 20 nTPM
memory CD4 T-cell: 19 nTPM

Brain region

cerebellum: 141 nTPM
hypothalamus: 131 nTPM
cerebral cortex: 122 nTPM
choroid plexus: 115 nTPM
white matter: 110 nTPM
basal ganglia: 98 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HNRNPD.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 58 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual disability
HNRNPD-related neurodevelopmental disorder
Neurodevelopmental disorder

ReferencesPubMed · IEDB

Publications for HNRNPD from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

1 publication

AUF1, the regulator of tumor necrosis factor alpha messenger RNA decay, is targeted by autoantibodies of patients with systemic rheumatic diseases.
2008 · Arthritis Rheum · RCR 0.4 · 21 citations

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 2.45
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HNRNPD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HNRNPD as an antibody target. Whether an autoantibody or antibody against HNRNPD could matter depends on whether native HNRNPD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HNRNPD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HNRNPD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...