Seroatlas · Human Serome Atlas

RBMS1

RNA-binding motif, single-stranded-interacting protein 1

Also known as: C2orf12, DKFZp564H0764, HCC-4, MSSP-1, MSSP-2, MSSP-3, RBMS1_HUMAN, SCR2, YC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P29558
Gene
RBMS1
Ensembl
ENSG00000153250
Chromosome
2
Canonical length
406 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Several transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. A pseudogene for this locus is found on chromosome 12. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>P29558|RBMS1
     1  MGKVWKQQMY PQYATYYYPQ YLQAKQSLVP AHPMAPPSPS TTSSNNNSSS SSNSGWDQLS
    61  KTNLYIRGLP PHTTDQDLVK LCQPYGKIVS TKAILDKTTN KCKGYGFVDF DSPAAAQKAV
   121  SALKASGVQA QMAKQQEQDP TNLYISNLPL SMDEQELENM LKPFGQVIST RILRDSSGTS
   181  RGVGFARMES TEKCEAVIGH FNGKFIKTPP GVSAPTEPLL CKFADGGQKK RQNPNKYIPN
   241  GRPWHREGEV RLAGMTLTYD PTTAAIQNGF YPSPYSIATN RMITQTSITP YIASPVSAYQ
   301  VQSPSWMQPQ PYILQHPGAV LTPSMEHTMS LQPASMISPL AQQMSHLSLG STGTYMPATS
   361  AMQGAYLPQY AHMQTTAVPV EEASGQQQVA VETSNDHSPY TFQPNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBMS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
52 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 52 nTPM
  • urinary bladder: 37 nTPM
  • smooth muscle: 36 nTPM
  • parathyroid gland: 35 nTPM
  • adipose tissue: 35 nTPM
  • endometrium: 30 nTPM

Single-cell type

  • podocytes: 1,016 nCPM
  • neutrophils: 972 nCPM
  • syncytiotrophoblasts: 899 nCPM
  • fibro-adipogenic progenitors: 576 nCPM
  • innate lymphoid cells: 571 nCPM
  • urothelial cells: 511 nCPM

Immune cell

  • neutrophil: 43 nTPM
  • MAIT T-cell: 30 nTPM
  • eosinophil: 26 nTPM
  • naive CD4 T-cell: 24 nTPM
  • classical monocyte: 21 nTPM
  • memory CD4 T-cell: 15 nTPM

Brain region

  • choroid plexus: 34 nTPM
  • pons: 29 nTPM
  • medulla oblongata: 26 nTPM
  • thalamus: 26 nTPM
  • basal ganglia: 25 nTPM
  • midbrain: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.12
gnomAD missense Z
1.66
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBMS1 as an antibody target. Whether an autoantibody or antibody against RBMS1 could matter depends on whether native RBMS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBMS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBMS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RBMS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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