Seroatlas · Human Serome Atlas

RBPMS

RNA-binding protein with multiple splicing

Also known as: HERMES, RBPMS_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q93062
Gene
RBPMS
Ensembl
ENSG00000157110
Chromosome
8
Canonical length
196 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

196 residues, UniProt reviewed canonical sequence.

>Q93062|RBPMS
     1  MNNGGKAEKE NTPSEANLQE EEVRTLFVSG LPLDIKPREL YLLFRPFKGY EGSLIKLTSK
    61  QPVGFVSFDS RSEAEAAKNA LNGIRFDPEI PQTLRLEFAK ANTKMAKNKL VGTPNPSTPL
   121  PNTVPQFIAR EPYELTVPAL YPSSPEVWAP YPLYPAELAP ALPPPAFTYP ASLHAQMRWL
   181  PPSEATSQGW KSRQFC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBPMS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
552 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 552 nTPM
  • colon: 337 nTPM
  • urinary bladder: 322 nTPM
  • adipose tissue: 229 nTPM
  • fallopian tube: 201 nTPM
  • kidney: 195 nTPM

Single-cell type

  • podocytes: 2,053 nCPM
  • renal collecting duct principal cells: 1,714 nCPM
  • renal connecting tubule cells: 1,597 nCPM
  • vascular smooth muscle cells: 1,337 nCPM
  • renal collecting duct intercalated cells: 1,262 nCPM
  • proximal tubule cells: 1,141 nCPM

Immune cell

  • plasmacytoid DC: 1 nTPM
  • NK-cell: 0.2 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • thalamus: 54 nTPM
  • pons: 44 nTPM
  • midbrain: 41 nTPM
  • basal ganglia: 41 nTPM
  • choroid plexus: 38 nTPM
  • hypothalamus: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
0.97
gnomAD missense Z
1.72
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBPMS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBPMS as an antibody target. Whether an autoantibody or antibody against RBPMS could matter depends on whether native RBPMS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBPMS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBPMS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RBPMS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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