Seroatlas · Human Serome Atlas

EIF3B

Eukaryotic translation initiation factor 3 subunit B

Also known as: EIF3B_HUMAN, EIF3S9, PRT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55884
Gene
EIF3B
Ensembl
ENSG00000106263
Chromosome
7
Canonical length
814 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in several processes, including IRES-dependent viral translational initiation; translational initiation; and viral translational termination-reinitiation. Located in cytoplasmic stress granule. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

814 residues, UniProt reviewed canonical sequence.

>P55884|EIF3B
     1  MQDAENVAVP EAAEERAEPG QQQPAAEPPP AEGLLRPAGP GAPEAAGTEA SSEEVGIAEA
    61  GPESEVRTEP AAEAEAASGP SESPSPPAAE ELPGSHAEPP VPAQGEAPGE QARDERSDSR
   121  AQAVSEDAGG NEGRAAEAEP RALENGDADE PSFSDPEDFV DDVSEEELLG DVLKDRPQEA
   181  DGIDSVIVVD NVPQVGPDRL EKLKNVIHKI FSKFGKITND FYPEEDGKTK GYIFLEYASP
   241  AHAVDAVKNA DGYKLDKQHT FRVNLFTDFD KYMTISDEWD IPEKQPFKDL GNLRYWLEEA
   301  ECRDQYSVIF ESGDRTSIFW NDVKDPVSIE ERARWTETYV RWSPKGTYLA TFHQRGIALW
   361  GGEKFKQIQR FSHQGVQLID FSPCERYLVT FSPLMDTQDD PQAIIIWDIL TGHKKRGFHC
   421  ESSAHWPIFK WSHDGKFFAR MTLDTLSIYE TPSMGLLDKK SLKISGIKDF SWSPGGNIIA
   481  FWVPEDKDIP ARVTLMQLPT RQEIRVRNLF NVVDCKLHWQ KNGDYLCVKV DRTPKGTQGV
   541  VTNFEIFRMR EKQVPVDVVE MKETIIAFAW EPNGSKFAVL HGEAPRISVS FYHVKNNGKI
   601  ELIKMFDKQQ ANTIFWSPQG QFVVLAGLRS MNGALAFVDT SDCTVMNIAE HYMASDVEWD
   661  PTGRYVVTSV SWWSHKVDNA YWLWTFQGRL LQKNNKDRFC QLLWRPRPPT LLSQEQIKQI
   721  KKDLKKYSKI FEQKDRLSQS KASKELVERR RTMMEDFRKY RKMAQELYME QKNERLELRG
   781  GVDTDELDSN VDDWEEETIE FFVTEEIIPL GNQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
146 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 146 nTPM
  • bone marrow: 84 nTPM
  • pancreas: 79 nTPM
  • skin: 78 nTPM
  • esophagus: 74 nTPM
  • colon: 69 nTPM

Single-cell type

  • erythrocyte progenitors: 242 nCPM
  • breast lactating cells: 242 nCPM
  • suprabasal keratinocytes: 153 nCPM
  • pancreatic acinar cells: 152 nCPM
  • gastric progenitor cells: 140 nCPM
  • megakaryocyte progenitors: 130 nCPM

Immune cell

  • NK-cell: 17 nTPM
  • T-reg: 9.5 nTPM
  • MAIT T-cell: 9.4 nTPM
  • naive CD8 T-cell: 8.5 nTPM
  • naive CD4 T-cell: 8.4 nTPM
  • memory CD8 T-cell: 8.2 nTPM

Brain region

  • white matter: 47 nTPM
  • pons: 47 nTPM
  • medulla oblongata: 46 nTPM
  • midbrain: 45 nTPM
  • spinal cord: 45 nTPM
  • hypothalamus: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.07
gnomAD pLI
1
gnomAD missense Z
1.82
DepMap mean gene effect
-1.77
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF3B as an antibody target. Whether an autoantibody or antibody against EIF3B could matter depends on whether native EIF3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF3B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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