Seroatlas · Human Serome Atlas

RBMS2

RNA-binding motif, single-stranded-interacting protein 2

Also known as: RBMS2_HUMAN, SCR3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15434
Gene: RBMS2
Ensembl: ENSG00000076067
Chromosome: 12
Canonical length: 407 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>Q15434|RBMS2
     1  MLLSVTSRPG ISTFGYNRNN KKPYVSLAQQ MAPPSPSNST PNSSSGSNGN DQLSKTNLYI
    61  RGLQPGTTDQ DLVKLCQPYG KIVSTKAILD KTTNKCKGYG FVDFDSPSAA QKAVTALKAS
   121  GVQAQMAKQQ EQDPTNLYIS NLPLSMDEQE LEGMLKPFGQ VISTRILRDT SGTSRGVGFA
   181  RMESTEKCEA IITHFNGKYI KTPPGVPAPS DPLLCKFADG GPKKRQNQGK FVQNGRAWPR
   241  NADMGVMALT YDPTTALQNG FYPAPYNITP NRMLAQSALS PYLSSPVSSY QRVTQTSPLQ
   301  VPNPSWMHHH SYLMQPSGSV LTPGMDHPIS LQPASMMGPL TQQLGHLSLS STGTYMPTAA
   361  AMQGAYISQY TPVPSSSVSV EESSGQQNQV AVDAPSEHGV YSFQFNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBMS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

lung: 35 nTPM
placenta: 22 nTPM
adipose tissue: 18 nTPM
thyroid gland: 17 nTPM
breast: 17 nTPM
heart muscle: 15 nTPM

Single-cell type

vascular endothelial cells: 235 nCPM
alveolar cells type 1: 231 nCPM
transitional alveolar cells: 148 nCPM
lymphatic endothelial cells: 131 nCPM
podocytes: 121 nCPM
extravillous trophoblasts: 120 nCPM

Immune cell

classical monocyte: 4.7 nTPM
myeloid DC: 2.8 nTPM
eosinophil: 1.6 nTPM
neutrophil: 1.6 nTPM
intermediate monocyte: 1.4 nTPM
memory CD8 T-cell: 1.2 nTPM

Brain region

thalamus: 39 nTPM
choroid plexus: 38 nTPM
cerebral cortex: 37 nTPM
medulla oblongata: 37 nTPM
pons: 34 nTPM
amygdala: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 0.84
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

RNA processing

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBMS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBMS2 as an antibody target. Whether an autoantibody or antibody against RBMS2 could matter depends on whether native RBMS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBMS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBMS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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