Seroatlas · Human Serome Atlas

EIF4B

Eukaryotic translation initiation factor 4B

Also known as: IF4B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P23588
Gene: EIF4B
Ensembl: ENSG00000063046
Chromosome: 12
Canonical length: 611 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Located in cytosol. Biomarker of autism spectrum disorder and major depressive disorder. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

611 residues, UniProt reviewed canonical sequence.

>P23588|EIF4B
     1  MAASAKKKNK KGKTISLTDF LAEDGGTGGG STYVSKPVSW ADETDDLEGD VSTTWHSNDD
    61  DVYRAPPIDR SILPTAPRAA REPNIDRSRL PKSPPYTAFL GNLPYDVTEE SIKEFFRGLN
   121  ISAVRLPREP SNPERLKGFG YAEFEDLDSL LSALSLNEES LGNRRIRVDV ADQAQDKDRD
   181  DRSFGRDRNR DSDKTDTDWR ARPATDSFDD YPPRRGDDSF GDKYRDRYDS DRYRDGYRDG
   241  YRDGPRRDMD RYGGRDRYDD RGSRDYDRGY DSRIGSGRRA FGSGYRRDDD YRGGGDRYED
   301  RYDRRDDRSW SSRDDYSRDD YRRDDRGPPQ RPKLNLKPRS TPKEDDSSAS TSQSTRAASI
   361  FGGAKPVDTA AREREVEERL QKEQEKLQRQ LDEPKLERRP RERHPSWRSE ETQERERSRT
   421  GSESSQTGTS TTSSRNARRR ESEKSLENET LNKEEDCHSP TSKPPKPDQP LKVMPAPPPK
   481  ENAWVKRSSN PPARSQSSDT EQQSPTSGGG KVAPAQPSEE GPGRKDENKV DGMNAPKGQT
   541  GNSSRGPGDG GNRDHWKESD RKDGKKDQDS RSAPEPKKPE ENPASKFSSA SKYAALSVDG
   601  EDENEGEDYA E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 511 nTPM

Expression across tissuesHPA

Tissue

ovary: 511 nTPM
skeletal muscle: 478 nTPM
tongue: 338 nTPM
tonsil: 275 nTPM
thymus: 269 nTPM
pancreas: 263 nTPM

Single-cell type

late spermatids: 908 nCPM
pancreatic acinar cells: 405 nCPM
erythrocyte progenitors: 373 nCPM
salivary acinar cells: 327 nCPM
extravillous trophoblasts: 271 nCPM
breast secretory cells: 270 nCPM

Immune cell

naive CD4 T-cell: 160 nTPM
MAIT T-cell: 153 nTPM
naive CD8 T-cell: 149 nTPM
total PBMC: 147 nTPM
memory CD4 T-cell: 127 nTPM
memory CD8 T-cell: 116 nTPM

Brain region

spinal cord: 226 nTPM
cerebellum: 213 nTPM
white matter: 208 nTPM
medulla oblongata: 203 nTPM
choroid plexus: 202 nTPM
basal ganglia: 198 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.12
gnomAD pLI: 1
gnomAD missense Z: 2.15
DepMap mean gene effect: -0.54
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
RNA recognition motif
Eukaryotic translation initiation factor 4B, RNA recognition motif

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF4B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF4B as an antibody target. Whether an autoantibody or antibody against EIF4B could matter depends on whether native EIF4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF4B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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