Seroatlas · Human Serome Atlas

CELF3

CUGBP Elav-like family member 3

Also known as: BRUNOL1, CAGH4, CELF3_HUMAN, ERDA4, MGC57297, TNRC4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5SZQ8
Gene
CELF3
Ensembl
ENSG00000159409
Chromosome
1
Canonical length
465 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>Q5SZQ8|CELF3
     1  MKEPDAIKLF VGQIPRHLEE KDLKPIFEQF GRIFELTVIK DKYTGLHKGC AFLTYCARDS
    61  ALKAQSALHE QKTLPGMNRP IQVKPADSES RGEDRKLFVG MLGKQQTDED VRKMFEPFGT
   121  IDECTVLRGP DGTSKGCAFV KFQTHAEAQA AINTLHSSRT LPGASSSLVV KFADTEKERG
   181  LRRMQQVATQ LGMFSPIALQ FGAYSAYTQA LMQQQAALVA AHSAYLSPMA TMAAVQMQHM
   241  AAINANGLIA TPITPSSGTS TPPAIAATPV SAIPAALGVN GYSPVPTQPT GQPAPDALYP
   301  NGVHPYPAQS PAAPVDPLQQ AYAGMQHYTA AYPAAYSLVA PAFPQPPALV AQQPPPPPQQ
   361  QQQQQQQQQQ QQQREGPDGC NIFIYHLPQE FTDSEILQMF VPFGHVISAK VFVDRATNQS
   421  KCFGFVSFDN PASAQAAIQA MNGFQIGMKR LKVQLKRPKD ANRPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CELF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
105 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 105 nTPM
  • cerebellum: 99 nTPM
  • basal ganglia: 85 nTPM
  • cerebral cortex: 81 nTPM
  • hippocampal formation: 72 nTPM
  • amygdala: 71 nTPM

Single-cell type

  • retinal bipolar cells: 101 nCPM
  • lactotrophs: 86 nCPM
  • adrenal medulla cells: 75 nCPM
  • neuroendocrine cells: 55 nCPM
  • thyrotrophs: 53 nCPM
  • cone photoreceptor cells: 44 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 123 nTPM
  • hippocampal formation: 118 nTPM
  • amygdala: 105 nTPM
  • basal ganglia: 102 nTPM
  • hypothalamus: 97 nTPM
  • cerebellum: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.77
gnomAD missense Z
3.3
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CELF3 as an antibody target. Whether an autoantibody or antibody against CELF3 could matter depends on whether native CELF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CELF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CELF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CELF3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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