Seroatlas · Human Serome Atlas

G3BP2

Ras GTPase-activating protein-binding protein 2

Also known as: G3BP2_HUMAN, KIAA0660

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UN86
Gene: G3BP2
Ensembl: ENSG00000138757
Chromosome: 4
Canonical length: 482 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol
Quaternary structure: Homooligomer

OverviewNCBI Gene

Enables molecular condensate scaffold activity. Involved in positive regulation of stress granule assembly; protein homooligomerization; and stress granule assembly. Located in cytoplasmic stress granule and cytosol. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

482 residues, UniProt reviewed canonical sequence.

>Q9UN86|G3BP2
     1  MVMEKPSPLL VGREFVRQYY TLLNKAPEYL HRFYGRNSSY VHGGVDASGK PQEAVYGQND
    61  IHHKVLSLNF SECHTKIRHV DAHATLSDGV VVQVMGLLSN SGQPERKFMQ TFVLAPEGSV
   121  PNKFYVHNDM FRYEDEVFGD SEPELDEESE DEVEEEQEER QPSPEPVQEN ANSGYYEAHP
   181  VTNGIEEPLE ESSHEPEPEP ESETKTEELK PQVEEKNLEE LEEKSTTPPP AEPVSLPQEP
   241  PKAFSWASVT SKNLPPSGTV SSSGIPPHVK APVSQPRVEA KPEVQSQPPR VREQRPRERP
   301  GFPPRGPRPG RGDMEQNDSD NRRIIRYPDS HQLFVGNLPH DIDENELKEF FMSFGNVVEL
   361  RINTKGVGGK LPNFGFVVFD DSEPVQRILI AKPIMFRGEV RLNVEEKKTR AARERETRGG
   421  GDDRRDIRRN DRGPGGPRGI VGGGMMRDRD GRGPPPRGGM AQKLGSGRGT GQMEGRFTGQ
   481  RR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against G3BP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 112 nTPM

Expression across tissuesHPA

Tissue

tongue: 112 nTPM
skeletal muscle: 97 nTPM
cerebral cortex: 84 nTPM
prostate: 73 nTPM
thyroid gland: 70 nTPM
bone marrow: 65 nTPM

Single-cell type

myonuclei: 796 nCPM
late spermatids: 341 nCPM
platelets: 341 nCPM
early spermatids: 266 nCPM
innate lymphoid cells: 252 nCPM
t-cells: 243 nCPM

Immune cell

basophil: 83 nTPM
MAIT T-cell: 76 nTPM
non-classical monocyte: 64 nTPM
total PBMC: 64 nTPM
eosinophil: 63 nTPM
NK-cell: 60 nTPM

Brain region

hypothalamus: 167 nTPM
cerebral cortex: 156 nTPM
basal ganglia: 130 nTPM
pons: 128 nTPM
midbrain: 120 nTPM
white matter: 117 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 3.61
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of G3BP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads G3BP2 as an antibody target. Whether an autoantibody or antibody against G3BP2 could matter depends on whether native G3BP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

G3BP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label G3BP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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