Seroatlas · Human Serome Atlas

BOLL

Protein boule-like

Also known as: BOLL_HUMAN, BOULE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N9W6
Gene
BOLL
Ensembl
ENSG00000152430
Chromosome
2
Canonical length
283 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mid piece,Principal piece,End piece,Annulus

OverviewNCBI Gene

This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

283 residues, UniProt reviewed canonical sequence.

>Q8N9W6|BOLL
     1  MQTDSLSPSP NPVSPVPLNN PTSAPRYGTV IPNRIFVGGI DFKTNESDLR KFFSQYGSVK
    61  EVKIVNDRAG VSKGYGFVTF ETQEDAQKIL QEAEKLNYKD KKLNIGPAIR KQQVGIPRSS
   121  IMPAAGTMYL TTSTGYPYTY HNGVAYFHTP EVTSVPPPWP SRSVCSSPVM VAQPIYQQPA
   181  YHYQATTQYL PGQWQWSVPQ PSASSAPFLY LQPSEVIYQP VEIAQDGGCV PPPLSLMETS
   241  VPEPYSDHGV QATYHQVYAP SAITMPAPVM QPEPIKTVWS IHY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BOLL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • testis: 46 nTPM
  • skeletal muscle: 3.5 nTPM
  • tongue: 1.2 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • late primary spermatocytes: 508 nCPM
  • early primary spermatocytes: 217 nCPM
  • late spermatids: 185 nCPM
  • early spermatids: 137 nCPM
  • differentiating spermatogonia: 52 nCPM
  • myonuclei: 33 nCPM

Immune cell

  • T-reg: 1.5 nTPM
  • basophil: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.9 nTPM
  • hippocampal formation: 0.7 nTPM
  • thalamus: 0.7 nTPM
  • white matter: 0.7 nTPM
  • amygdala: 0.6 nTPM
  • basal ganglia: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0.06
gnomAD missense Z
0.87
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BOLL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BOLL as an antibody target. Whether an autoantibody or antibody against BOLL could matter depends on whether native BOLL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BOLL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BOLL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BOLL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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