Seroatlas · Human Serome Atlas

SRSF6

Serine/arginine-rich splicing factor 6

Also known as: B52, SFRS6, SRP55, SRSF6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13247
Gene
SRSF6
Ensembl
ENSG00000124193
Chromosome
20
Canonical length
344 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q13247|SRSF6
     1  MPRVYIGRLS YNVREKDIQR FFSGYGRLLE VDLKNGYGFV EFEDSRDADD AVYELNGKEL
    61  CGERVIVEHA RGPRRDRDGY SYGSRSGGGG YSSRRTSGRD KYGPPVRTEY RLIVENLSSR
   121  CSWQDLKDFM RQAGEVTYAD AHKERTNEGV IEFRSYSDMK RALDKLDGTE INGRNIRLIE
   181  DKPRTSHRRS YSGSRSRSRS RRRSRSRSRR SSRSRSRSIS KSRSRSRSRS KGRSRSRSKG
   241  RKSRSKSKSK PKSDRGSHSH SRSRSKDEYE KSRSRSRSRS PKENGKGDIK SKSRSRSQSR
   301  SNSPLPVPPS KARSVSPPPK RATSRSRSRS RSKSRSRSRS SSRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRSF6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
109 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 109 nTPM
  • pancreas: 67 nTPM
  • epididymis: 56 nTPM
  • ovary: 56 nTPM
  • spleen: 55 nTPM
  • adrenal gland: 55 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 130 nCPM
  • oligodendrocytes: 103 nCPM
  • bergmann glia: 90 nCPM
  • astrocytes: 81 nCPM
  • choroid plexus epithelial cells: 81 nCPM
  • microglia: 62 nCPM

Immune cell

  • intermediate monocyte: 33 nTPM
  • non-classical monocyte: 30 nTPM
  • naive CD4 T-cell: 27 nTPM
  • basophil: 26 nTPM
  • naive CD8 T-cell: 26 nTPM
  • myeloid DC: 25 nTPM

Brain region

  • choroid plexus: 78 nTPM
  • white matter: 63 nTPM
  • cerebellum: 53 nTPM
  • hypothalamus: 50 nTPM
  • cerebral cortex: 49 nTPM
  • basal ganglia: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.91
gnomAD missense Z
1.1
DepMap mean gene effect
-0.53
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRSF6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRSF6 as an antibody target. Whether an autoantibody or antibody against SRSF6 could matter depends on whether native SRSF6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRSF6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRSF6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRSF6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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