Seroatlas · Human Serome Atlas

SRSF7

Serine/arginine-rich splicing factor 7

Also known as: 9G8, AAG3, HSSG1, RBM37, SFRS7, SRSF7_HUMAN, ZCCHC20, ZCRB2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16629
Gene
SRSF7
Ensembl
ENSG00000115875
Chromosome
2
Canonical length
238 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an N-terminal RNA recognition motif (RRM) for binding RNA and a C-terminal RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2018]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>Q16629|SRSF7
     1  MSRYGRYGGE TKVYVGNLGT GAGKGELERA FSYYGPLRTV WIARNPPGFA FVEFEDPRDA
    61  EDAVRGLDGK VICGSRVRVE LSTGMPRRSR FDRPPARRPF DPNDRCYECG EKGHYAYDCH
   121  RYSRRRRSRS RSRSHSRSRG RRYSRSRSRS RGRRSRSASP RRSRSISLRR SRSASLRRSR
   181  SGSIKGSRYF QSPSRSRSRS RSISRPRSSR SKSRSPSPKR SRSPSGSPRR SASPERMD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRSF7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
125 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 125 nTPM
  • tonsil: 84 nTPM
  • thymus: 81 nTPM
  • lymph node: 67 nTPM
  • adipose tissue: 66 nTPM
  • urinary bladder: 64 nTPM

Single-cell type

  • breast lactating cells: 935 nCPM
  • t-cells: 697 nCPM
  • extravillous trophoblasts: 629 nCPM
  • pdcs: 557 nCPM
  • breast myoepithelial cells: 521 nCPM
  • migrating cytotrophoblasts: 476 nCPM

Immune cell

  • myeloid DC: 143 nTPM
  • intermediate monocyte: 103 nTPM
  • plasmacytoid DC: 86 nTPM
  • total PBMC: 78 nTPM
  • classical monocyte: 71 nTPM
  • NK-cell: 66 nTPM

Brain region

  • choroid plexus: 29 nTPM
  • white matter: 29 nTPM
  • hypothalamus: 29 nTPM
  • cerebral cortex: 28 nTPM
  • spinal cord: 28 nTPM
  • cerebellum: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
2.72
DepMap mean gene effect
-2.11
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRSF7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRSF7 as an antibody target. Whether an autoantibody or antibody against SRSF7 could matter depends on whether native SRSF7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRSF7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRSF7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRSF7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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