Seroatlas · Human Serome Atlas

TRMT2A

tRNA (uracil-5-)-methyltransferase homolog A

Also known as: HTF9C, TRM2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZ69
Gene: TRMT2A
Ensembl: ENSG00000099899
Chromosome: 22
Canonical length: 625 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

625 residues, UniProt reviewed canonical sequence.

>Q8IZ69|TRMT2A
     1  MSENLDNEGP KPMESCGQES SSALSCPTVS VPPAAPAALE EVEKEGAGAA TGPGPQPGLY
    61  SYIRDDLFTS EIFKLELQNV PRHASFSDVR RFLGRFGLQP HKTKLFGQPP CAFVTFRSAA
   121  ERDKALRVLH GALWKGRPLS VRLARPKADP MARRRRQEGE SEPPVTRVAD VVTPLWTVPY
   181  AEQLERKQLE CEQVLQKLAK EIGSTNRALL PWLLEQRHKH NKACCPLEGV RPSPQQTEYR
   241  NKCEFLVGVG VDGEDNTVGC RLGKYKGGTC AVAAPFDTVH IPEATKQVVK AFQEFIRSTP
   301  YSAYDPETYT GHWKQLTVRT SRRHQAMAIA YFHPQKLSPE ELAELKTSLA QHFTAGPGRA
   361  SGVTCLYFVE EGQRKTPSQE GLPLEHVAGD RCIHEDLLGL TFRISPHAFF QVNTPAAEVL
   421  YTVIQDWAQL DAGSMVLDVC CGTGTIGLAL ARKVKRVIGV ELCPEAVEDA RVNAQDNELS
   481  NVEFHCGRAE DLVPTLVSRL ASQHLVAILD PPRAGLHSKV ILAIRRAKNL RRLLYVSCNP
   541  RAAMGNFVDL CRAPSNRVKG IPFRPVKAVA VDLFPQTPHC EMLILFERVE HPNGTGVLGP
   601  HSPPAQPTPG PPDNTLQETG TFPSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRMT2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

liver: 32 nTPM
spleen: 28 nTPM
adrenal gland: 24 nTPM
pancreas: 24 nTPM
testis: 23 nTPM
pituitary gland: 22 nTPM

Single-cell type

late spermatids: 351 nCPM
early spermatids: 166 nCPM
megakaryocytes: 37 nCPM
syncytiotrophoblasts: 35 nCPM
tuft cells: 35 nCPM
hofbauer cells: 32 nCPM

Immune cell

intermediate monocyte: 16 nTPM
MAIT T-cell: 15 nTPM
myeloid DC: 15 nTPM
non-classical monocyte: 14 nTPM
total PBMC: 13 nTPM
plasmacytoid DC: 13 nTPM

Brain region

white matter: 16 nTPM
medulla oblongata: 15 nTPM
pons: 14 nTPM
thalamus: 14 nTPM
choroid plexus: 14 nTPM
cerebellum: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding
tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent
C-methyltransferase activity

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
(Uracil-5)-methyltransferase family
Nucleotide-binding alpha-beta plait domain superfamily
S-adenosyl-L-methionine-dependent methyltransferase superfamily
RNA-binding domain superfamily
tRNA (uracil(54)-C(5))-methyltransferase, metazoa type
TRMT2A, RNA recognition motif
tRNA (Uracil-5-)-methyltransferase

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRMT2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRMT2A as an antibody target. Whether an autoantibody or antibody against TRMT2A could matter depends on whether native TRMT2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRMT2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRMT2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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