Seroatlas · Human Serome Atlas

IGF2BP3

Insulin-like growth factor 2 mRNA-binding protein 3

Also known as: CT98, IF2B3_HUMAN, IMP-3, IMP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00425
Gene: IGF2BP3
Ensembl: ENSG00000136231
Chromosome: 7
Canonical length: 579 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol
Quaternary structure: Homooligomer

OverviewNCBI Gene

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

579 residues, UniProt reviewed canonical sequence.

>O00425|IGF2BP3
     1  MNKLYIGNLS ENAAPSDLES IFKDAKIPVS GPFLVKTGYA FVDCPDESWA LKAIEALSGK
    61  IELHGKPIEV EHSVPKRQRI RKLQIRNIPP HLQWEVLDSL LVQYGVVESC EQVNTDSETA
   121  VVNVTYSSKD QARQALDKLN GFQLENFTLK VAYIPDEMAA QQNPLQQPRG RRGLGQRGSS
   181  RQGSPGSVSK QKPCDLPLRL LVPTQFVGAI IGKEGATIRN ITKQTQSKID VHRKENAGAA
   241  EKSITILSTP EGTSAACKSI LEIMHKEAQD IKFTEEIPLK ILAHNNFVGR LIGKEGRNLK
   301  KIEQDTDTKI TISPLQELTL YNPERTITVK GNVETCAKAE EEIMKKIRES YENDIASMNL
   361  QAHLIPGLNL NALGLFPPTS GMPPPTSGPP SAMTPPYPQF EQSETETVHL FIPALSVGAI
   421  IGKQGQHIKQ LSRFAGASIK IAPAEAPDAK VRMVIITGPP EAQFKAQGRI YGKIKEENFV
   481  SPKEEVKLEA HIRVPSFAAG RVIGKGGKTV NELQNLSSAE VVVPRDQTPD ENDQVVVKIT
   541  GHFYACQVAQ RKIQEILTQV KQHQQQKALQ SGPPQSRRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGF2BP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

placenta: 27 nTPM
tonsil: 6.9 nTPM
testis: 4.8 nTPM
lymph node: 4 nTPM
esophagus: 1.9 nTPM
thymus: 1.4 nTPM

Single-cell type

extravillous trophoblasts: 349 nCPM
cytotrophoblasts: 295 nCPM
platelets: 278 nCPM
syncytiotrophoblasts: 240 nCPM
migrating cytotrophoblasts: 213 nCPM
hofbauer cells: 187 nCPM

Immune cell

total PBMC: 0.7 nTPM
naive B-cell: 0.5 nTPM
classical monocyte: 0.4 nTPM
memory B-cell: 0.3 nTPM
neutrophil: 0.3 nTPM
intermediate monocyte: 0.2 nTPM

Brain region

amygdala: 3.5 nTPM
cerebral cortex: 3 nTPM
basal ganglia: 2.9 nTPM
hypothalamus: 2.9 nTPM
hippocampal formation: 2.6 nTPM
cerebellum: 2.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGF2BP3.

Disease | ImmuneIEDB

Conditions an epitope on IGF2BP3 was assayed in.

head and neck squamous cell carcinoma T cell
glioblastoma T cell
esophageal cancer T cell
colorectal cancer T cell
esophagus squamous cell carcinoma T cell
intrahepatic gall duct cancer T cell
extrahepatic bile duct carcinoma T cell
gallbladder cancer T cell
esophageal carcinoma T cell
skin melanoma T cell
malignant astrocytoma T cell
cholangiocarcinoma T cell
lung cancer T cell
stomach cancer T cell
head and neck cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.1
gnomAD pLI: 1
gnomAD missense Z: 2.12
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IGF2BP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGF2BP3 as an antibody target. Whether an autoantibody or antibody against IGF2BP3 could matter depends on whether native IGF2BP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGF2BP3 is annotated at the cell surface, where native IGF2BP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGF2BP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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