Seroatlas · Human Serome Atlas

NONO

Non-POU domain-containing octamer-binding protein

Also known as: NMT55, NONO_HUMAN, NRB54, P54, P54NRB, PPP1R114

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15233
Gene
NONO
Ensembl
ENSG00000147140
Chromosome
X
Canonical length
471 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nucleoli,Nucleoli fibrillar center

OverviewNCBI Gene

This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

471 residues, UniProt reviewed canonical sequence.

>Q15233|NONO
     1  MQSNKTFNLE KQNHTPRKHH QHHHQQQHHQ QQQQQPPPPP IPANGQQASS QNEGLTIDLK
    61  NFRKPGEKTF TQRSRLFVGN LPPDITEEEM RKLFEKYGKA GEVFIHKDKG FGFIRLETRT
   121  LAEIAKVELD NMPLRGKQLR VRFACHSASL TVRNLPQYVS NELLEEAFSV FGQVERAVVI
   181  VDDRGRPSGK GIVEFSGKPA ARKALDRCSE GSFLLTTFPR PVTVEPMDQL DDEEGLPEKL
   241  VIKNQQFHKE REQPPRFAQP GSFEYEYAMR WKALIEMEKQ QQDQVDRNIK EAREKLEMEM
   301  EAARHEHQVM LMRQDLMRRQ EELRRMEELH NQEVQKRKQL ELRQEEERRR REEEMRRQQE
   361  EMMRRQQEGF KGTFPDAREQ EIRMGQMAMG GAMGINNRGA MPPAPVPAGT PAPPGPATMM
   421  PDGTLGLTPP TTERFGQAAT MEGIGAIGGT PPAFNRAAPG AEFAPNKRRR Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NONO can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
238 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 238 nTPM
  • ovary: 199 nTPM
  • tonsil: 155 nTPM
  • pancreas: 134 nTPM
  • lymph node: 128 nTPM
  • adrenal gland: 118 nTPM

Single-cell type

  • extravillous trophoblasts: 201 nCPM
  • megakaryocyte progenitors: 199 nCPM
  • migrating cytotrophoblasts: 179 nCPM
  • kupffer cells: 170 nCPM
  • megakaryocyte-erythroid progenitors: 165 nCPM
  • erythrocyte progenitors: 160 nCPM

Immune cell

  • total PBMC: 178 nTPM
  • non-classical monocyte: 141 nTPM
  • T-reg: 128 nTPM
  • MAIT T-cell: 120 nTPM
  • intermediate monocyte: 120 nTPM
  • NK-cell: 120 nTPM

Brain region

  • cerebellum: 94 nTPM
  • hypothalamus: 92 nTPM
  • choroid plexus: 81 nTPM
  • midbrain: 75 nTPM
  • white matter: 73 nTPM
  • medulla oblongata: 73 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NONO.

Disease | AllUniProt

Conditions NONO is implicated in, by any mechanism.

  • Intellectual developmental disorder, X-linked, syndromic 34 (MRXS34) MIM:300967

Disease | GeneticClinVar

33 pathogenic / likely-pathogenic of 257 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on NONO was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
0.99
gnomAD missense Z
3.59
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NONO in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NONO as an antibody target. Whether an autoantibody or antibody against NONO could matter depends on whether native NONO is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NONO is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NONO as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NONO. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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