Seroatlas · Human Serome Atlas

RBMX2

RNA-binding motif protein, X-linked 2

Also known as: CGI-79, RBMX2_HUMAN, Snu17

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y388
Gene: RBMX2
Ensembl: ENSG00000134597
Chromosome: X
Canonical length: 322 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane,Nucleoli,Endoplasmic reticulum

OverviewNCBI Gene

Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in endoplasmic reticulum; nuclear membrane; and nucleolus. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

322 residues, UniProt reviewed canonical sequence.

>Q9Y388|RBMX2
     1  MNPLTKVKLI NELNEREVQL GVADKVSWHS EYKDSAWIFL GGLPYELTEG DIICVFSQYG
    61  EIVNINLVRD KKTGKSKGFC FLCYEDQRST ILAVDNFNGI KIKGRTIRVD HVSNYRAPKD
   121  SEEIDDVTRQ LQEKGCGART PSPSLSESSE DEKPTKKHKK DKKEKKKKKK EKEKADREVQ
   181  AEQPSSSSPR RKTVKEKDDT GPKKHSSKNS ERAQKSEPRE GQKLPKSRTA YSGGAEDLER
   241  ELKKEKPKHE HKSSSRREAR EEKTRIRDRG RSSDAHSSWY NGRSEGRSYR SRSRSRDKSH
   301  RHKRARRSRE RESSNPSDRW RH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBMX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 23 nTPM
cervix: 18 nTPM
ovary: 18 nTPM
thymus: 16 nTPM
tonsil: 16 nTPM
epididymis: 15 nTPM

Single-cell type

oocytes: 405 nCPM
decidual stromal cells: 78 nCPM
undifferentiated spermatogonia: 57 nCPM
esophageal basal cells: 57 nCPM
epididymal efferent duct absorptive cells: 54 nCPM
ovarian stromal cells: 53 nCPM

Immune cell

T-reg: 13 nTPM
memory B-cell: 10 nTPM
naive CD4 T-cell: 9.8 nTPM
naive CD8 T-cell: 9.3 nTPM
memory CD4 T-cell: 9.1 nTPM
memory CD8 T-cell: 9.1 nTPM

Brain region

cerebral cortex: 20 nTPM
white matter: 17 nTPM
hypothalamus: 16 nTPM
midbrain: 15 nTPM
hippocampal formation: 14 nTPM
amygdala: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.94
gnomAD missense Z: 0.92
DepMap mean gene effect: -0.64
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
RNA recognition motif
Ist3-like, RNA recognition motif
RNA Processing and Spliceosome Component

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBMX2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBMX2 as an antibody target. Whether an autoantibody or antibody against RBMX2 could matter depends on whether native RBMX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBMX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBMX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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