GRSF1

Protein identityUniProt · HPA

UniProt accession

Q12849

Gene

GRSF1

Ensembl

ENSG00000132463

Chromosome

4

Canonical length

480 aa

Protein class

Predicted intracellular proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

480 residues, UniProt reviewed canonical sequence.

>Q12849|GRSF1
     1  MAGTRWVLGA LLRGCGCNCS SCRRTGAACL PFYSAAGSIP SGVSGRRRLL LLLGAAAAAA
    61  SQTRGLQTGP VPPGRLAGPP AVATSAAAAA AASYSALRAS LLPQSLAAAA AVPTRSYSQE
   121  SKTTYLEDLP PPPEYELAPS KLEEEVDDVF LIRAQGLPWS CTMEDVLNFF SDCRIRNGEN
   181  GIHFLLNRDG KRRGDALIEM ESEQDVQKAL EKHRMYMGQR YVEVYEINNE DVDALMKSLQ
   241  VKSSPVVNDG VVRLRGLPYS CNEKDIVDFF AGLNIVDITF VMDYRGRRKT GEAYVQFEEP
   301  EMANQALLKH REEIGNRYIE IFPSRRNEVR THVGSYKGKK IASFPTAKYI TEPEMVFEEH
   361  EVNEDIQPMT AFESEKEIEL PKEVPEKLPE AADFGTTSSL HFVHMRGLPF QANAQDIINF
   421  FAPLKPVRIT MEYSSSGKAT GEADVHFETH EDAVAAMLKD RSHVHHRYIE LFLNSCPKGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRSF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

242 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.23

gnomAD pLI

0

gnomAD missense Z

-0.51

DepMap mean gene effect

-0.24

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• anterior/posterior pattern specification
• mitochondrial RNA catabolic process
• morphogenesis of embryonic epithelium
• mRNA processing
• positive regulation of mitochondrial RNA catabolic process
• regulation of RNA splicing
• tRNA processing

Molecular functions

• G-quadruplex RNA binding
• mRNA binding
• RNA binding

Cellular components

• cytoplasm
• mitochondrial matrix
• mitochondrial nucleoid
• mitochondrion
• nucleoplasm
• ribonucleoprotein complex
• ribonucleoprotein granule

Protein domainsUniProt · Pfam · InterPro

• RNA recognition motif domain
• Nucleotide-binding alpha-beta plait domain superfamily
• RNA-binding domain superfamily
• Epithelial Splicing Regulatory
• RNA recognition motif
• GRSF-1, RNA recognition motif 2
• GRSF-1, RNA recognition motif 1
• GRSF-1, RNA recognition motif 3

KeywordsUniProt

• Cytoplasm
• Mitochondrion
• mRNA processing
• Phosphoprotein
• Repeat
• RNA-binding
• Transit peptide
• tRNA processing

InteractionsUniProt · HPA

Protein binding partners of GRSF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PNPT1
• SUPV3L1
• TRMT10C
• PSMD10
• RPS6KA3