Seroatlas · Human Serome Atlas

CELF6

CUGBP Elav-like family member 6

Also known as: BRUNOL6, CELF6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96J87
Gene: CELF6
Ensembl: ENSG00000140488
Chromosome: 15
Canonical length: 481 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

481 residues, UniProt reviewed canonical sequence.

>Q96J87|CELF6
     1  MAAAPGGSAQ PAGPGPRLGF STADSGVGMS GLNPGPAVPM KDHDAIKLFV GQIPRGLDEQ
    61  DLKPLFEEFG RIYELTVLKD RLTGLHKGCA FLTYCARDSA LKAQSALHEQ KTLPGMNRPI
   121  QVKPAASEGR GEDRKLFVGM LGKQQGEEDV RRLFQPFGHI EECTVLRSPD GTSKGCAFVK
   181  FGSQGEAQAA IRGLHGSRTM AGASSSLVVK LADTDRERAL RRMQQMAGHL GAFHPAPLPL
   241  GACGAYTTAI LQHQAALLAA AQGPGLGPVA AVAAQMQHVA AFSLVAAPLL PAAAANSPPG
   301  SGPGTLPGLP APIGVNGFGP LTPQTNGQPG SDTLYNNGLS PYPAQSPGVA DPLQQAYAGM
   361  HHYAAAYPSA YAPVSTAFPQ QPSALPQQQR EGPEGCNLFI YHLPQEFGDA ELIQTFLPFG
   421  AVVSAKVFVD RATNQSKCFG FVSFDNPTSA QTAIQAMNGF QIGMKRLKVQ LKRPKDANRP
   481  Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CELF6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 28 nTPM
pituitary gland: 23 nTPM
retina: 20 nTPM
kidney: 17 nTPM
cerebral cortex: 16 nTPM
cerebellum: 14 nTPM

Single-cell type

other brain neurons: 3 nCPM
astrocytes: 1.1 nCPM
bergmann glia: 1 nCPM
brain excitatory neurons: 1 nCPM
brain inhibitory neurons: 0.9 nCPM
microglia: 0.5 nCPM

Immune cell

eosinophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 57 nTPM
midbrain: 48 nTPM
pons: 46 nTPM
basal ganglia: 34 nTPM
cerebral cortex: 33 nTPM
thalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0
gnomAD missense Z: 2.56
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CELF6 as an antibody target. Whether an autoantibody or antibody against CELF6 could matter depends on whether native CELF6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CELF6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CELF6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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