Seroatlas · Human Serome Atlas

SRSF9

Serine/arginine-rich splicing factor 9

Also known as: SFRS9, SRp30c, SRSF9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13242
Gene
SRSF9
Ensembl
ENSG00000111786
Chromosome
12
Canonical length
221 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two pseudogenes, one on chromosome 15 and the other on chromosome 21, have been found for this gene. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

221 residues, UniProt reviewed canonical sequence.

>Q13242|SRSF9
     1  MSGWADERGG EGDGRIYVGN LPTDVREKDL EDLFYKYGRI REIELKNRHG LVPFAFVRFE
    61  DPRDAEDAIY GRNGYDYGQC RLRVEFPRTY GGRGGWPRGG RNGPPTRRSD FRVLVSGLPP
   121  SGSWQDLKDH MREAGDVCYA DVQKDGVGMV EYLRKEDMEY ALRKLDDTKF RSHEGETSYI
   181  RVYPERSTSY GYSRSRSGSR GRDSPYQSRG SPHYFSPFRP Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRSF9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
128 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 128 nTPM
  • adrenal gland: 112 nTPM
  • pancreas: 108 nTPM
  • kidney: 95 nTPM
  • testis: 94 nTPM
  • spleen: 87 nTPM

Single-cell type

  • extravillous trophoblasts: 486 nCPM
  • syncytiotrophoblasts: 466 nCPM
  • esophageal apical cells: 449 nCPM
  • migrating cytotrophoblasts: 384 nCPM
  • megakaryocytes: 383 nCPM
  • cytotrophoblasts: 340 nCPM

Immune cell

  • eosinophil: 48 nTPM
  • memory B-cell: 40 nTPM
  • naive B-cell: 35 nTPM
  • plasmacytoid DC: 29 nTPM
  • basophil: 29 nTPM
  • non-classical monocyte: 27 nTPM

Brain region

  • thalamus: 64 nTPM
  • choroid plexus: 63 nTPM
  • midbrain: 60 nTPM
  • cerebral cortex: 60 nTPM
  • hypothalamus: 59 nTPM
  • pons: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0.64
gnomAD missense Z
2.53
DepMap mean gene effect
-0.29
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRSF9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRSF9 as an antibody target. Whether an autoantibody or antibody against SRSF9 could matter depends on whether native SRSF9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRSF9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRSF9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRSF9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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