Seroatlas · Human Serome Atlas

POLDIP3

Polymerase delta-interacting protein 3

Also known as: KIAA1649, PDIP3, PDIP3_HUMAN, PDIP46, SKAR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BY77
Gene
POLDIP3
Ensembl
ENSG00000100227
Chromosome
22
Canonical length
421 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Cytoplasmic bodies

OverviewNCBI Gene

This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>Q9BY77|POLDIP3
     1  MADISLDELI RKRGAAAKGR LNARPGVGGV RSRVGIQQGL LSQSTRTATF QQRFDARQKI
    61  GLSDARLKLG VKDAREKLLQ KDARFRIKGK VQDAREMLNS RKQQTTVPQK PRQVADAREK
   121  ISLKRSSPAA FINPPIGTVT PALKLTKTIQ VPQQKAMAPL HPHPAGMRIN VVNNHQAKQN
   181  LYDLDEDDDG IASVPTKQMK FAASGGFLHH MAGLSSSKLS MSKALPLTKV VQNDAYTAPA
   241  LPSSIRTKAL TNMSRTLVNK EEPPKELPAA EPVLSPLEGT KMTVNNLHPR VTEEDIVELF
   301  CVCGALKRAR LVHPGVAEVV FVKKDDAITA YKKYNNRCLD GQPMKCNLHM NGNVITSDQP
   361  ILLRLSDSPS MKKESELPRR VNSASSSNPP AEVDPDTILK ALFKSSGASV TTQPTEFKIK
   421  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POLDIP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
86 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 86 nTPM
  • bone marrow: 60 nTPM
  • fallopian tube: 50 nTPM
  • thymus: 45 nTPM
  • tonsil: 43 nTPM
  • cervix: 42 nTPM

Single-cell type

  • oligodendrocytes: 30 nCPM
  • renal collecting duct intercalated cells: 28 nCPM
  • loop of henle epithelial cells: 26 nCPM
  • renal collecting duct principal cells: 25 nCPM
  • bergmann glia: 25 nCPM
  • epididymal principal cells: 25 nCPM

Immune cell

  • myeloid DC: 40 nTPM
  • total PBMC: 38 nTPM
  • classical monocyte: 35 nTPM
  • intermediate monocyte: 34 nTPM
  • non-classical monocyte: 30 nTPM
  • gdT-cell: 30 nTPM

Brain region

  • medulla oblongata: 62 nTPM
  • white matter: 57 nTPM
  • basal ganglia: 53 nTPM
  • thalamus: 51 nTPM
  • midbrain: 49 nTPM
  • pons: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.12
gnomAD missense Z
0.12
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POLDIP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POLDIP3 as an antibody target. Whether an autoantibody or antibody against POLDIP3 could matter depends on whether native POLDIP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POLDIP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POLDIP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/POLDIP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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