Seroatlas · Human Serome Atlas

SAFB2

Scaffold attachment factor B2

Also known as: KIAA0138, SAFB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14151
Gene: SAFB2
Ensembl: ENSG00000130254
Chromosome: 19
Canonical length: 953 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Vesicles

OverviewNCBI Gene

The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of estrogen receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, apoptosis, differentiation, the stress response, and regulation of immune genes. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

953 residues, UniProt reviewed canonical sequence.

>Q14151|SAFB2
     1  MAETLPGSGD SGPGTASLGP GVAETGTRRL SELRVIDLRA ELKKRNLDTG GNKSVLMERL
    61  KKAVKEEGQD PDEIGIELEA TSKKSAKRCV KGLKMEEEGT EDNGLEDDSR DGQEDMEASL
   121  ENLQNMGMMD MSVLDETEVA NSSAPDFGED GTDGLLDSFC DSKEYVAAQL RQLPAQPPEH
   181  AVDGEGFKNT LETSSLNFKV TPDIEESLLE PENEKILDIL GETCKSEPVK EESSELEQPF
   241  AQDTSSVGPD RKLAEEEDLF DSAHPEEGDL DLASESTAHA QSSKADSLLA VVKREPAEQP
   301  GDGERTDCEP VGLEPAVEQS SAASELAEAS SEELAEAPTE APSPEARDSK EDGRKFDFDA
   361  CNEVPPAPKE SSTSEGADQK MSSFKEEKDI KPIIKDEKGR VGSGSGRNLW VSGLSSTTRA
   421  TDLKNLFSKY GKVVGAKVVT NARSPGARCY GFVTMSTSDE ATKCISHLHR TELHGRMISV
   481  EKAKNEPAGK KLSDRKECEV KKEKLSSVDR HHSVEIKIEK TVIKKEEKIE KKEEKKPEDI
   541  KKEEKDQDEL KPGPTNRSRV TKSGSRGMER TVVMDKSKGE PVISVKTTSR SKERSSKSQD
   601  RKSESKEKRD ILSFDKIKEQ RERERQRQRE REIRETERRR EREQREREQR LEAFHERKEK
   661  ARLQRERLQL ECQRQRLERE RMERERLERE RMRVERERRK EQERIHRERE ELRRQQEQLR
   721  YEQERRPGRR PYDLDRRDDA YWPEGKRVAM EDRYRADFPR PDHRFHDFDH RDRGQYQDHA
   781  IDRREGSRPM MGDHRDGQHY GDDRHGHGGP PERHGRDSRD GWGGYGSDKR LSEGRGLPPP
   841  PRGGRDWGEH NQRLEEHQAR AWQGAMDAGA ASREHARWQG GERGLSGPSG PGHMASRGGV
   901  AGRGGFAQGG HSQGHVVPGG GLEGGGVASQ DRGSRVPHPH PHPPPYPHFT RRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAFB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 70 nTPM
ovary: 58 nTPM
pituitary gland: 50 nTPM
cervix: 48 nTPM
fallopian tube: 45 nTPM
prostate: 44 nTPM

Single-cell type

cardiomyocytes: 227 nCPM
sertoli cells: 207 nCPM
pituicytes/fscs: 183 nCPM
proximal tubule cells: 176 nCPM
epicardial cells: 152 nCPM
endometrial stromal cells: 110 nCPM

Immune cell

basophil: 43 nTPM
neutrophil: 24 nTPM
eosinophil: 22 nTPM
MAIT T-cell: 17 nTPM
naive B-cell: 15 nTPM
gdT-cell: 15 nTPM

Brain region

cerebral cortex: 53 nTPM
hypothalamus: 53 nTPM
cerebellum: 49 nTPM
white matter: 47 nTPM
medulla oblongata: 42 nTPM
midbrain: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SAFB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAFB2 as an antibody target. Whether an autoantibody or antibody against SAFB2 could matter depends on whether native SAFB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAFB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAFB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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