Seroatlas · Human Serome Atlas

CELF1

CUGBP Elav-like family member 1

Also known as: BRUNOL2, CELF1_HUMAN, CUG-BP, CUGBP, CUGBP1, EDEN-BP, hNab50, NAB50, NAPOR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92879
Gene: CELF1
Ensembl: ENSG00000149187
Chromosome: 11
Canonical length: 486 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

486 residues, UniProt reviewed canonical sequence.

>Q92879|CELF1
     1  MNGTLDHPDQ PDLDAIKMFV GQVPRTWSEK DLRELFEQYG AVYEINVLRD RSQNPPQSKG
    61  CCFVTFYTRK AALEAQNALH NMKVLPGMHH PIQMKPADSE KNNAVEDRKL FIGMISKKCT
   121  ENDIRVMFSS FGQIEECRIL RGPDGLSRGC AFVTFTTRAM AQTAIKAMHQ AQTMEGCSSP
   181  MVVKFADTQK DKEQKRMAQQ LQQQMQQISA ASVWGNLAGL NTLGPQYLAL YLQLLQQTAS
   241  SGNLNTLSSL HPMGGLNAMQ LQNLAALAAA ASAAQNTPSG TNALTTSSSP LSVLTSSGSS
   301  PSSSSSNSVN PIASLGALQT LAGATAGLNV GSLAGMAALN GGLGSSGLSN GTGSTMEALT
   361  QAYSGIQQYA AAALPTLYNQ NLLTQQSIGA AGSQKEGPEG ANLFIYHLPQ EFGDQDLLQM
   421  FMPFGNVVSA KVFIDKQTNL SKCFGFVSYD NPVSAQAAIQ SMNGFQIGMK RLKVQLKRSK
   481  NDSKPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CELF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 62 nTPM
cerebellum: 49 nTPM
tongue: 49 nTPM
liver: 48 nTPM
parathyroid gland: 40 nTPM
bone marrow: 40 nTPM

Single-cell type

neutrophils: 636 nCPM
neutrophil progenitors: 399 nCPM
hepatocytes: 336 nCPM
choroid plexus epithelial cells: 330 nCPM
sertoli cells: 320 nCPM
monocytes: 305 nCPM

Immune cell

eosinophil: 23 nTPM
non-classical monocyte: 18 nTPM
MAIT T-cell: 16 nTPM
naive B-cell: 15 nTPM
neutrophil: 15 nTPM
memory CD8 T-cell: 14 nTPM

Brain region

cerebellum: 132 nTPM
basal ganglia: 107 nTPM
amygdala: 92 nTPM
choroid plexus: 91 nTPM
cerebral cortex: 89 nTPM
hippocampal formation: 88 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 3.34
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CELF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CELF1 as an antibody target. Whether an autoantibody or antibody against CELF1 could matter depends on whether native CELF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CELF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CELF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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