HNRNPA1L3
Heterogeneous nuclear ribonucleoprotein A1-like 3
Also known as: HNRNPA1P48, RA1L3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A2R8Y4L2
- Gene
- HNRNPA1L3
- Ensembl
- ENSG00000224578
- Chromosome
- 16
- Canonical length
- 320 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
320 residues, UniProt reviewed canonical sequence.
>A0A2R8Y4L2|HNRNPA1L3
1 MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN TKRSRGFGFV
61 TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPDA HLTVKKIFVG GIKEDTEEHH
121 LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA
181 LSKQEMASAS SSQRGRSGSG NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS
241 GDGYNGFGND GSNFGGGGSY NDFGNYNNQS SNFGPMKGGN FEGRSSGPHG GGGQYFAKPR
301 NQGGYGGSSS SSSYGSGRRFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HNRNPA1L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 9 nTPM
Expression across tissuesHPA
Tissue
- ovary: 9 nTPM
- appendix: 7.1 nTPM
- duodenum: 7.1 nTPM
- endometrium: 6.6 nTPM
- bone marrow: 6.3 nTPM
- small intestine: 6 nTPM
Single-cell type
- extravillous trophoblasts: 104 nCPM
- migrating cytotrophoblasts: 87 nCPM
- cytotrophoblasts: 70 nCPM
- epididymal basal cells: 66 nCPM
- syncytiotrophoblasts: 65 nCPM
- enteric stem cells: 64 nCPM
Immune cell
- total PBMC: 28 nTPM
- naive CD4 T-cell: 21 nTPM
- NK-cell: 20 nTPM
- naive CD8 T-cell: 20 nTPM
- MAIT T-cell: 18 nTPM
- T-reg: 17 nTPM
Brain region
- white matter: 3.1 nTPM
- spinal cord: 2.9 nTPM
- cerebellum: 2.8 nTPM
- pons: 2.6 nTPM
- medulla oblongata: 2.5 nTPM
- cerebral cortex: 2.4 nTPM
OntologyGO
Biological processes
- via spliceosome
- mRNA splicing
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- RNA recognition motif domain
- Nucleotide-binding alpha-beta plait domain superfamily
- Heterogeneous nuclear ribonucleoprotein A1/A2, C-terminal
- hnRNP A1/3, RNA recognition motif 2
- hnRNP A1, RNA recognition motif 1
- RNA-binding domain superfamily
- RNA recognition motif
- Heterogeneous nuclear ribonucleoprotein A1, LC domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HNRNPA1L3 as an antibody target. Whether an autoantibody or antibody against HNRNPA1L3 could matter depends on whether native HNRNPA1L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HNRNPA1L3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HNRNPA1L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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