Seroatlas · Human Serome Atlas

MATR3

Matrin-3

Also known as: KIAA0723, MATR3_HUMAN, MGC9105, MPD2, VCPDM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P43243
Gene
MATR3
Ensembl
ENSG00000015479
Chromosome
5
Canonical length
847 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

847 residues, UniProt reviewed canonical sequence.

>P43243|MATR3
     1  MSKSFQQSSL SRDSQGHGRD LSAAGIGLLA AATQSLSMPA SLGRMNQGTA RLASLMNLGM
    61  SSSLNQQGAH SALSSASTSS HNLQSIFNIG SRGPLPLSSQ HRGDADQASN ILASFGLSAR
   121  DLDELSRYPE DKITPENLPQ ILLQLKRRRT EEGPTLSYGR DGRSATREPP YRVPRDDWEE
   181  KRHFRRDSFD DRGPSLNPVL DYDHGSRSQE SGYYDRMDYE DDRLRDGERC RDDSFFGETS
   241  HNYHKFDSEY ERMGRGPGPL QERSLFEKKR GAPPSSNIED FHGLLPKGYP HLCSICDLPV
   301  HSNKEWSQHI NGASHSRRCQ LLLEIYPEWN PDNDTGHTMG DPFMLQQSTN PAPGILGPPP
   361  PSFHLGGPAV GPRGNLGAGN GNLQGPRHMQ KGRVETSRVV HIMDFQRGKN LRYQLLQLVE
   421  PFGVISNHLI LNKINEAFIE MATTEDAQAA VDYYTTTPAL VFGKPVRVHL SQKYKRIKKP
   481  EGKPDQKFDQ KQELGRVIHL SNLPHSGYSD SAVLKLAEPY GKIKNYILMR MKSQAFIEME
   541  TREDAMAMVD HCLKKALWFQ GRCVKVDLSE KYKKLVLRIP NRGIDLLKKD KSRKRSYSPD
   601  GKESPSDKKS KTDGSQKTES STEGKEQEEK SGEDGEKDTK DDQTEQEPNM LLESEDELLV
   661  DEEEAAALLE SGSSVGDETD LANLGDVASD GKKEPSDKAV KKDGSASAAA KKKLKKVDKI
   721  EELDQENEAA LENGIKNEEN TEPGAESSEN ADDPNKDTSE NADGQSDENK DDYTIPDEYR
   781  IGPYQPNVPV GIDYVIPKTG FYCKLCSLFY TNEEVAKNTH CSSLPHYQKL KKFLNKLAEE
   841  RRQKKET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MATR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
305 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 305 nTPM
  • cerebellum: 252 nTPM
  • retina: 207 nTPM
  • thymus: 207 nTPM
  • cerebral cortex: 203 nTPM
  • ovary: 184 nTPM

Single-cell type

  • megakaryocytes: 12 nCPM
  • medullary thymic epithelial cells: 4.8 nCPM
  • megakaryocyte progenitors: 3.7 nCPM
  • fallopian secretory cells: 3.6 nCPM
  • fallopian tube ciliated cells: 3.4 nCPM
  • corticotrophs: 3.3 nCPM

Immune cell

  • basophil: 188 nTPM
  • total PBMC: 160 nTPM
  • NK-cell: 152 nTPM
  • T-reg: 137 nTPM
  • MAIT T-cell: 135 nTPM
  • naive CD4 T-cell: 125 nTPM

Brain region

  • cerebellum: 276 nTPM
  • cerebral cortex: 244 nTPM
  • basal ganglia: 239 nTPM
  • white matter: 237 nTPM
  • hypothalamus: 223 nTPM
  • spinal cord: 221 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MATR3.

Disease | AllUniProt

Conditions MATR3 is implicated in, by any mechanism.

  • Amyotrophic lateral sclerosis 21 (ALS21) MIM:606070

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 705 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Amyotrophic lateral sclerosis type 21

Disease | ImmuneIEDB

Conditions an epitope on MATR3 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.08
gnomAD pLI
1
gnomAD missense Z
2.73
DepMap mean gene effect
-0.31
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MATR3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MATR3 as an antibody target. Whether an autoantibody or antibody against MATR3 could matter depends on whether native MATR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MATR3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MATR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MATR3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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