Seroatlas · Human Serome Atlas

RBM19

Probable RNA-binding protein 19

Also known as: DKFZp586F1023, KIAA0682, Mrd1, RBM19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y4C8
Gene: RBM19
Ensembl: ENSG00000122965
Chromosome: 12
Canonical length: 960 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

This gene encodes a nucleolar protein that contains six RNA-binding motifs. The encoded protein may be involved in regulating ribosome biogenesis. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

960 residues, UniProt reviewed canonical sequence.

>Q9Y4C8|RBM19
     1  MSRLIVKNLP NGMKEERFRQ LFAAFGTLTD CSLKFTKDGK FRKFGFIGFK SEEEAQKAQK
    61  HFNKSFIDTS RITVEFCKSF GDPAKPRAWS KHAQKPSQPK QPPKDSTTPE IKKDEKKKKV
   121  AGQLEKLKED TEFQEFLSVH QRRAQAATWA NDGLDAEPSK GKSKPASDYL NFDSDSGQES
   181  EEEGAGEDLE EEASLEPKAA VQKELSDMDY LKSKMVKAGS SSSSEEEESE DEAVHCDEGS
   241  EAEEEDSSAT PVLQERDSKG AGQEQGMPAG KKRPPEARAE TEKPANQKEP TTCHTVKLRG
   301  APFNVTEKNV MEFLAPLKPV AIRIVRNAHG NKTGYIFVDF SNEEEVKQAL KCNREYMGGR
   361  YIEVFREKNV PTTKGAPKNT TKSWQGRILG ENEEEEDLAE SGRLFVRNLP YTSTEEDLEK
   421  LFSKYGPLSE LHYPIDSLTK KPKGFAFITF MFPEHAVKAY SEVDGQVFQG RMLHVLPSTI
   481  KKEASEDASA LGSSSYKKKK EAQDKANSAS SHNWNTLFMG PNAVADAIAQ KYNATKSQVF
   541  DHETKGSVAV RVALGETQLV QEVRRFLIDN GVSLDSFSQA AAERSKTVIL VKNLPAGTLA
   601  AQLQETFGHF GSLGRVLLPE GGITAIVEFL EPLEARKAFR HLAYSKFHHV PLYLEWAPVG
   661  VFSSTAPQKK KLQDTPSEPM EKDPAEPETV PDGETPEDEN PTEEGADNSS AKMEEEEEEE
   721  EEEEESLPGC TLFIKNLNFD TTEEKLKEVF SKVGTVKSCS ISKKKNKAGV LLSMGFGFVE
   781  YRKPEQAQKA LKQLQGHVVD GHKLEVRISE RATKPAVTLA RKKQVPRKQT TSKILVRNIP
   841  FQAHSREIRE LFSTFGELKT VRLPKKMTGT GTHRGFGFVD FLTKQDAKRA FNALCHSTHL
   901  YGRRLVLEWA DSEVTLQALR RKTAAHFHEP PKKKRSVVLD EILEQLEGSD SDSEEQTLQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 20 nTPM
ovary: 18 nTPM
skeletal muscle: 16 nTPM
bone marrow: 16 nTPM
kidney: 15 nTPM
prostate: 14 nTPM

Single-cell type

microglia: 78 nCPM
erythrocyte progenitors: 54 nCPM
epicardial cells: 50 nCPM
renal collecting duct intercalated cells: 43 nCPM
b-cells: 43 nCPM
megakaryocyte-erythroid progenitors: 42 nCPM

Immune cell

non-classical monocyte: 13 nTPM
gdT-cell: 7.7 nTPM
intermediate monocyte: 7.7 nTPM
NK-cell: 7.6 nTPM
memory B-cell: 7.3 nTPM
memory CD8 T-cell: 6.4 nTPM

Brain region

white matter: 34 nTPM
thalamus: 32 nTPM
cerebral cortex: 31 nTPM
pons: 29 nTPM
medulla oblongata: 29 nTPM
basal ganglia: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0
gnomAD missense Z: -0.18
DepMap mean gene effect: -0.77
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
RNA recognition motif domain, eukaryotic-type
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
RRM MRD1 RNA Processing and Ribosome Biogenesis
RNA recognition motif
Probable RNA-binding protein 19, RNA recognition motif 2
Probable RNA-binding protein 19, RNA recognition motif 1
Probable RNA-binding protein 19, RNA recognition motif 3
Probable RNA-binding protein 19, RNA recognition motif 4
Probable RNA-binding protein 19, RNA recognition motif 6
Probable RNA-binding protein 19, RNA recognition motif 5

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM19 as an antibody target. Whether an autoantibody or antibody against RBM19 could matter depends on whether native RBM19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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