RBMS3

Protein identityUniProt · HPA

UniProt accession

Q6XE24

Gene

RBMS3

Ensembl

ENSG00000144642

Chromosome

3

Canonical length

437 aa

Protein class

Predicted intracellular proteins

Subcellular location

Vesicles

OverviewNCBI Gene

This gene encodes an RNA-binding protein that belongs to the c-myc gene single-strand binding protein family. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. The encoded protein was isolated by virtue of its binding to an upstream element of the alpha2(I) collagen promoter. The observation that this protein localizes mostly in the cytoplasm suggests that it may be involved in a cytoplasmic function such as controlling RNA metabolism, rather than transcription. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

437 residues, UniProt reviewed canonical sequence.

>Q6XE24|RBMS3
     1  MGKRLDQPQM YPQYTYYYPH YLQTKQSYAP APHPMAPPSP STNSSSNNSS NNSSGEQLSK
    61  TNLYIRGLPP GTTDQDLIKL CQPYGKIVST KAILDKNTNQ CKGYGFVDFD SPAAAQKAVA
   121  SLKANGVQAQ MAKQQEQDPT NLYISNLPIS MDEQELENML KPFGHVISTR ILRDANGVSR
   181  GVGFARMEST EKCEVVIQHF NGKYLKTPPG IPAPSEPLLC KFADGGQKKR QNQSKYTQNG
   241  RPWPREGEAG MALTYDPTAA IQNGFYSSPY SIATNRMIPQ TSITPFIAAS PVSTYQVQST
   301  SWMPHPPYVM QPTGAVITPT MDHPMSMQPA NMMGPLTQQM NHLSLGTTGT IQSQDRIMIL
   361  HQLLCQYMTA AAPMQGTYIP QYTPVPPTAV SIEGVVADTS PQTVAPSSQD TSGQQQQIAV
   421  DTSNEHAPAY SYQQSKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBMS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.58

Highest tissue expression

20 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.46

gnomAD pLI

0.21

gnomAD missense Z

1.27

DepMap mean gene effect

0.1

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• defense response to tumor cell
• negative regulation of canonical Wnt signaling pathway
• negative regulation of gene expression
• positive regulation of gene expression
• positive regulation of translation

Molecular functions

• mRNA 3'-UTR AU-rich region binding
• mRNA 3'-UTR binding
• poly(A) binding
• poly(U) RNA binding

Cellular components

• cytoplasm
• cytosol
• nucleus
• ribonucleoprotein complex

Protein domainsUniProt · Pfam · InterPro

• RNA recognition motif domain
• Paraneoplastic encephalomyelitis antigen
• Nucleotide-binding alpha-beta plait domain superfamily
• RNA-binding domain superfamily
• RNA recognition motif
• RBMS3, RNA recognition motif 2

KeywordsUniProt

• Cytoplasm
• Repeat
• RNA-binding