Seroatlas · Human Serome Atlas

SRSF8

Serine/arginine-rich splicing factor 8

Also known as: SFRS2B, SRP46, SRSF8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRL6
Gene: SRSF8
Ensembl: ENSG00000263465
Chromosome: 11
Canonical length: 282 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

282 residues, UniProt reviewed canonical sequence.

>Q9BRL6|SRSF8
     1  MSCGRPPPDV DGMITLKVDN LTYRTSPDSL RRVFEKYGRV GDVYIPREPH TKAPRGFAFV
    61  RFHDRRDAQD AEAAMDGAEL DGRELRVQVA RYGRRDLPRS RQGEPRGRSR GGGYGRRSRS
   121  YGRRSRSPRR RHRSRSRGPS CSRSRSRSRY RGSRYSRSPY SRSPYSRSRY SRSPYSRSRY
   181  RESRYGGSHY SSSGYSNSRY SRYHSSRSHS KSGSSTSSRS ASTSKSSSAR RSKSSSVSRS
   241  RSRSRSSSMT RSPPRVSKRK SKSRSRSKRP PKSPEEEGQM SS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRSF8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 22 nTPM
pancreas: 20 nTPM
cerebellum: 19 nTPM
blood vessel: 19 nTPM
spleen: 19 nTPM
salivary gland: 19 nTPM

Single-cell type

platelets: 242 nCPM
melanocytes: 106 nCPM
parietal cells: 92 nCPM
esophageal suprabasal cells: 90 nCPM
gastric chief cells: 87 nCPM
megakaryocytes: 80 nCPM

Immune cell

naive CD4 T-cell: 12 nTPM
T-reg: 11 nTPM
basophil: 10 nTPM
memory CD4 T-cell: 9.4 nTPM
memory B-cell: 9.2 nTPM
naive CD8 T-cell: 9.1 nTPM

Brain region

white matter: 22 nTPM
hypothalamus: 21 nTPM
choroid plexus: 20 nTPM
cerebral cortex: 19 nTPM
cerebellum: 19 nTPM
spinal cord: 19 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRSF8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRSF8 as an antibody target. Whether an autoantibody or antibody against SRSF8 could matter depends on whether native SRSF8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRSF8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRSF8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...