Seroatlas · Human Serome Atlas

MARF1

Meiosis regulator and mRNA stability factor 1

Also known as: KIAA0430, LKAP, LMKB, MARF1_HUMAN, PPP1R34

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y4F3
Gene: MARF1
Ensembl: ENSG00000166783
Chromosome: 16
Canonical length: 1742 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes a putative peroxisomal protein that appears to be conserved across Euteleostomi. In humans, it may be autoantigenic. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

1742 residues, UniProt reviewed canonical sequence.

>Q9Y4F3|MARF1
     1  MMEGNGTENS CSRTRGWLQQ DNDAKPWLWK FSNCFSRPEQ TLPHSPQTKE YMENKKVAVE
    61  LKDVPSPLHA GSKLFPAVPL PDIRSLQQPK IQLSSVPKVS CCAHCPNEPS TSPMRFGGGG
   121  GGSGGTSSLI HPGALLDSQS TRTITCQVGS GFAFQSASSL QNASARNNLA GIASDFPSMC
   181  LESNLSSCKH LPCCGKLHFQ SCHGNVHKLH QFPSLQGCTS AGYFPCSDFT SGAPGHLEEH
   241  ISQSELTPHL CTNSLHLNVV PPVCLKGSLY CEDCLNKPAR NSIIDAAKVW PNIPPPNTQP
   301  APLAVPLCNG CGTKGTGKET TLLLATSLGK AASKFGSPEV AVAGQVLENL PPIGVFWDIE
   361  NCSVPSGRSA TAVVQRIREK FFKGHREAEF ICVCDISKEN KEVIQELNNC QVTVAHINAT
   421  AKNAADDKLR QSLRRFANTH TAPATVVLVS TDVNFALELS DLRHRHGFHI ILVHKNQASE
   481  ALLHHANELI RFEEFISDLP PRLPLKMPQC HTLLYVYNLP ANKDGKSVSN RLRRLSDNCG
   541  GKVLSITGCS AILRFINQDS AERAQKRMEN EDVFGNRIIV SFTPKNRELC ETKSSNAIAD
   601  KVKSPKKLKN PKLCLIKDAS EQSSSAKATP GKGSQANSGS ATKNTNVKSL QELCRMESKT
   661  GHRNSEHQQG HLRLVVPTHG NSSAAVSTPK NSGVAEPVYK TSQKKENLSA RSVTSSPVEK
   721  KDKEETVFQV SYPSAFSKLV ASRQVSPLLA SQSWSSRSMS PNLLNRASPL AFNIANSSSE
   781  ADCPDPFANG ADVQVSNIDY RLSRKELQQL LQEAFARHGK VKSVELSPHT DYQLKAVVQM
   841  ENLQDAIGAV NSLHRYKIGS KKILVSLATG AASKSLSLLS AETMSVLQDA PACCLPLFKF
   901  TDIYEKKFGH KLNVSDLYKL TDTVAIREQG NGRLVCLLPS SQARQSPLGS SQSHDGSSTN
   961  CSPIIFEELE YHEPVCRQHC SNKDFSEHEF DPDSYKIPFV ILSLKTFAPQ VHSLLQTHEG
  1021  TVPLLSFPDC YIAEFGDLEV VQENQGGVPL EHFITCVPGV NIATAQNGIK VVKWIHNKPP
  1081  PPNTDPWLLR SKSPVGNPQL IQFSREVIDL LKSQPSCVIP ISHFIPSYHH HFAKQCRVSD
  1141  YGYSKLIELL EAVPHVLQIL GMGSKRLLTL THRAQVKRFT QDLLKLLKSQ ASKQVIVREF
  1201  SQAYHWCFSK DWDVTEYGVC ELIDIVSEIP DTTICLSQQD NEMVICIPKR ERTQDEIERT
  1261  KQFSKDVVDL LRHQPHFRMP FNKFIPSYHH HFGRQCKLAY YGFTKLLELF EAIPDTLQVL
  1321  ECGEEKILTL TEVERFKALA AQFVKLLRSQ KDNCLMMTDL LTEYAKTFGY TFRLQDYDVS
  1381  SISALTQKLC HVVKVADIES GRQIQLINRK SLRSLTAQLL VLLMSWEGTT HLSVEELKRH
  1441  YESTHNTPLN PCEYGFMTLT ELLKSLPYLV EVFTNDKMEE CVKLTSLYLF AKNVRSLLHT
  1501  YHYQQIFLHE FSMAYTKYVG ETLQPKTYGH SSVEELLGAI PQVVWIKGHG HKRIVVLKND
  1561  MKSRLSSLSL SPANHENQPS EGERILEVPE SHTASELKLG ADGSGPSHTE QELLRLTDDS
  1621  PVDLLCAPVP SCLPSPQLRP DPVILQSADL IQFEERPQEP SEIMILNQEE KMEIPIPGKS
  1681  KTLTSDSSSS CISAAVPVPP CPSSETSESL LSKDPVESPA KKQPKNRVKL AANFSLAPIT
  1741  KL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MARF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

tonsil: 21 nTPM
skeletal muscle: 17 nTPM
blood vessel: 17 nTPM
cerebellum: 15 nTPM
cerebral cortex: 15 nTPM
colon: 15 nTPM

Single-cell type

podocytes: 60 nCPM
microglia: 57 nCPM
oligodendrocytes: 54 nCPM
distal convoluted tubule cells: 52 nCPM
proximal tubule cells: 51 nCPM
loop of henle epithelial cells: 44 nCPM

Immune cell

neutrophil: 7.2 nTPM
naive B-cell: 5.2 nTPM
eosinophil: 4.6 nTPM
memory B-cell: 4.1 nTPM
basophil: 2.5 nTPM
naive CD4 T-cell: 1.9 nTPM

Brain region

cerebral cortex: 39 nTPM
midbrain: 37 nTPM
white matter: 35 nTPM
thalamus: 33 nTPM
basal ganglia: 33 nTPM
hypothalamus: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.12
gnomAD pLI: 1
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
Nucleotide-binding alpha-beta plait domain superfamily
OST-HTH/LOTUS domain
RNA-binding domain superfamily
LOTUS-like domain
RNA recognition motif
OST-HTH/LOTUS domain
NYN domain
Meiosis regulator and mRNA stability factor 1
MARF1, RNA recognition motif 1
MARF1, RNA recognition motif 2
MARF1, first and second LOTUS domain
NYN domain
MARF1, RNA recognition motif 1
MARF1 LOTUS domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MARF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LIMK2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MARF1 as an antibody target. Whether an autoantibody or antibody against MARF1 could matter depends on whether native MARF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MARF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

In humans, it may be autoantigenic.

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