Seroatlas · Human Serome Atlas

PABPC1

Polyadenylate-binding protein 1

Also known as: PAB1, PABP1, PABP1_HUMAN, PABPC2, PABPL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P11940
Gene
PABPC1
Ensembl
ENSG00000070756
Chromosome
8
Canonical length
636 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

636 residues, UniProt reviewed canonical sequence.

>P11940|PABPC1
     1  MNPSAPSYPM ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RVCRDMITRR SLGYAYVNFQ
    61  QPADAERALD TMNFDVIKGK PVRIMWSQRD PSLRKSGVGN IFIKNLDKSI DNKALYDTFS
   121  AFGNILSCKV VCDENGSKGY GFVHFETQEA AERAIEKMNG MLLNDRKVFV GRFKSRKERE
   181  AELGARAKEF TNVYIKNFGE DMDDERLKDL FGKFGPALSV KVMTDESGKS KGFGFVSFER
   241  HEDAQKAVDE MNGKELNGKQ IYVGRAQKKV ERQTELKRKF EQMKQDRITR YQGVNLYVKN
   301  LDDGIDDERL RKEFSPFGTI TSAKVMMEGG RSKGFGFVCF SSPEEATKAV TEMNGRIVAT
   361  KPLYVALAQR KEERQAHLTN QYMQRMASVR AVPNPVINPY QPAPPSGYFM AAIPQTQNRA
   421  AYYPPSQIAQ LRPSPRWTAQ GARPHPFQNM PGAIRPAAPR PPFSTMRPAS SQVPRVMSTQ
   481  RVANTSTQTM GPRPAAAAAA ATPAVRTVPQ YKYAAGVRNP QQHLNAQPQV TMQQPAVHVQ
   541  GQEPLTASML ASAPPQEQKQ MLGERLFPLI QAMHPTLAGK ITGMLLEIDN SELLHMLESP
   601  ESLRSKVDEA VAVLQAHQAK EAAQKAVNSA TGVPTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PABPC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
1,213 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 1,213 nTPM
  • esophagus: 696 nTPM
  • lymph node: 507 nTPM
  • tonsil: 499 nTPM
  • vagina: 479 nTPM
  • appendix: 463 nTPM

Single-cell type

  • esophageal apical cells: 8,506 nCPM
  • late primary spermatocytes: 2,562 nCPM
  • breast secretory cells: 1,926 nCPM
  • monocytes: 1,888 nCPM
  • monocyte progenitors: 1,719 nCPM
  • kupffer cells: 1,655 nCPM

Immune cell

  • total PBMC: 570 nTPM
  • non-classical monocyte: 471 nTPM
  • naive CD4 T-cell: 439 nTPM
  • myeloid DC: 422 nTPM
  • intermediate monocyte: 406 nTPM
  • classical monocyte: 403 nTPM

Brain region

  • medulla oblongata: 335 nTPM
  • thalamus: 311 nTPM
  • choroid plexus: 295 nTPM
  • pons: 285 nTPM
  • cerebral cortex: 281 nTPM
  • white matter: 281 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PABPC1.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 104 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on PABPC1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
1
gnomAD missense Z
4.49
DepMap mean gene effect
-0.98
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PABPC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PABPC1 as an antibody target. Whether an autoantibody or antibody against PABPC1 could matter depends on whether native PABPC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PABPC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PABPC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PABPC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...