Seroatlas · Human Serome Atlas

PABPC4L

Polyadenylate-binding protein 4-like

Also known as: PAB4L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CB38
Gene: PABPC4L
Ensembl: ENSG00000254535
Chromosome: 4
Canonical length: 370 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

370 residues, UniProt reviewed canonical sequence.

>P0CB38|PABPC4L
     1  MNVAAKYRMA SLYVGDLHAD VTEDLLFRKF STVGPVLSIR ICRDQVTRRS LGYAYVNFLQ
    61  LADAQKALDT MNFDIIKGKS IRLMWSQRDA YLRRSGIGNV FIKNLDKSID NKTLYEHFSA
   121  FGKILSSKVM SDDQGSKGYA FVHFQNQSAA DRAIEEMNGK LLKGCKVFVG RFKNRKDREA
   181  ELRSKASEFT NVYIKNFGGD MDDERLKDVF SKYGKTLSVK VMTDSSGKSK GFGFVSFDSH
   241  EAAKKAVEEM NGRDINGQLI FVGRAQKKVE RQAELKQMFE QLKRERIRGC QGVKLYIKNL
   301  DDTIDDEKLR NEFSSFGSIS RVKVMQEEGQ SKGFGLICFS SPEDATKAMT EMNGRILGSK
   361  PLSIALAQRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PABPC4L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 9.6 nTPM

Expression across tissuesHPA

Tissue

placenta: 9.6 nTPM
parathyroid gland: 5 nTPM
seminal vesicle: 3.9 nTPM
endometrium: 3.5 nTPM
ovary: 3.2 nTPM
prostate: 2.7 nTPM

Single-cell type

loop of henle epithelial cells: 0.8 nCPM
renal connecting tubule cells: 0.7 nCPM
proximal tubule cells: 0.5 nCPM
papillary tip epithelial cells: 0.4 nCPM
renal collecting duct intercalated cells: 0.4 nCPM
renal collecting duct principal cells: 0.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 1.6 nTPM
basal ganglia: 0.9 nTPM
amygdala: 0.7 nTPM
pons: 0.7 nTPM
spinal cord: 0.7 nTPM
white matter: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 1.47

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of gene expression

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PABPC4L as an antibody target. Whether an autoantibody or antibody against PABPC4L could matter depends on whether native PABPC4L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PABPC4L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PABPC4L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...