Seroatlas · Human Serome Atlas

HNRNPA1L2

Heterogeneous nuclear ribonucleoprotein A1-like 2

Also known as: LOC144983, RA1L2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q32P51
Gene: HNRNPA1L2
Ensembl: ENSG00000139675
Chromosome: 13
Canonical length: 320 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytoplasm and nucleus. Predicted to be part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

320 residues, UniProt reviewed canonical sequence.

>Q32P51|HNRNPA1L2
     1  MSKSASPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN TKRSRGFGFV
    61  TYATVEEVDA AMNTTPHKVD GRVVEPKRAV SREDSQRPGA HLTVKKIFVG GIKEDTEEHH
   121  LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF VTFDDHDSVD KIVIQKYHTV KGHNCEVRKA
   181  LPKQEMASAS SSQRGRRGSG NFGGGRGDGF GGNDNFGRGG NFSGRGGFGG SCGGGGYGGS
   241  GDGYNGFGND GSNFGGGGSY NDFGNYNNQS SNFGPMKGGN FGGRSSGPYG GGGQYFAKPQ
   301  NQGGYGVSSS SSSYGSGRRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HNRNPA1L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 18 nTPM
choroid plexus: 15 nTPM
ovary: 13 nTPM
thymus: 12 nTPM
retina: 11 nTPM
cerebellum: 10 nTPM

Single-cell type

loop of henle epithelial cells: 3.4 nCPM
proximal tubule cells: 3 nCPM
renal connecting tubule cells: 2.9 nCPM
distal convoluted tubule cells: 2.6 nCPM
podocytes: 2.1 nCPM
renal collecting duct intercalated cells: 2.1 nCPM

Immune cell

naive B-cell: 9.8 nTPM
plasmacytoid DC: 9.4 nTPM
NK-cell: 9.2 nTPM
total PBMC: 8.3 nTPM
eosinophil: 7.4 nTPM
naive CD4 T-cell: 7.3 nTPM

Brain region

cerebellum: 15 nTPM
hypothalamus: 14 nTPM
cerebral cortex: 12 nTPM
thalamus: 12 nTPM
white matter: 12 nTPM
choroid plexus: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HNRNPA1L2.

Disease | ImmuneIEDB

Conditions an epitope on HNRNPA1L2 was assayed in.

narcolepsy B cell
multiple sclerosis B cell
peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0.02
gnomAD missense Z: -0.07
DepMap mean gene effect: -0.32
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

mRNA 3'-UTR binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HNRNPA1L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HNRNPA1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HNRNPA1L2 as an antibody target. Whether an autoantibody or antibody against HNRNPA1L2 could matter depends on whether native HNRNPA1L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HNRNPA1L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HNRNPA1L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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