Seroatlas · Human Serome Atlas

EIF3G

Eukaryotic translation initiation factor 3 subunit G

Also known as: eIF3-delta, eIF3-p44, EIF3G_HUMAN, EIF3S4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75821
Gene
EIF3G
Ensembl
ENSG00000130811
Chromosome
19
Canonical length
320 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

320 residues, UniProt reviewed canonical sequence.

>O75821|EIF3G
     1  MPTGDFDSKP SWADQVEEEG EDDKCVTSEL LKGIPLATGD TSPEPELLPG APLPPPKEVI
    61  NGNIKTVTEY KIDEDGKKFK IVRTFRIETR KASKAVARRK NWKKFGNSEF DPPGPNVATT
   121  TVSDDVSMTF ITSKEDLNCQ EEEDPMNKLK GQKIVSCRIC KGDHWTTRCP YKDTLGPMQK
   181  ELAEQLGLST GEKEKLPGEL EPVQATQNKT GKYVPPSLRD GASRRGESMQ PNRRADDNAT
   241  IRVTNLSEDT RETDLQELFR PFGSISRIYL AKDKTTGQSK GFAFISFHRR EDAARAIAGV
   301  SGFGYDHLIL NVEWAKPSTN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF3G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
512 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 512 nTPM
  • pancreas: 312 nTPM
  • ovary: 272 nTPM
  • blood vessel: 222 nTPM
  • colon: 208 nTPM
  • tongue: 206 nTPM

Single-cell type

  • late spermatids: 2,427 nCPM
  • syncytiotrophoblasts: 596 nCPM
  • cytotrophoblasts: 591 nCPM
  • late primary spermatocytes: 496 nCPM
  • early spermatids: 438 nCPM
  • decidual stromal cells: 418 nCPM

Immune cell

  • NK-cell: 460 nTPM
  • total PBMC: 457 nTPM
  • T-reg: 353 nTPM
  • MAIT T-cell: 349 nTPM
  • classical monocyte: 320 nTPM
  • myeloid DC: 304 nTPM

Brain region

  • white matter: 99 nTPM
  • medulla oblongata: 98 nTPM
  • spinal cord: 95 nTPM
  • cerebellum: 92 nTPM
  • thalamus: 92 nTPM
  • basal ganglia: 91 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.99
gnomAD missense Z
2.17
DepMap mean gene effect
-1.25
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF3G in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF3G as an antibody target. Whether an autoantibody or antibody against EIF3G could matter depends on whether native EIF3G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF3G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF3G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF3G. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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