Seroatlas · Human Serome Atlas

NXF1

Nuclear RNA export factor 1

Also known as: DKFZp667O0311, Mex67, NXF1_HUMAN, TAP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBU9
Gene
NXF1
Ensembl
ENSG00000162231
Chromosome
11
Canonical length
619 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

619 residues, UniProt reviewed canonical sequence.

>Q9UBU9|NXF1
     1  MADEGKSYSE HDDERVNFPQ RKKKGRGPFR WKYGEGNRRS GRGGSGIRSS RLEEDDGDVA
    61  MSDAQDGPRV RYNPYTTRPN RRGDTWHDRD RIHVTVRRDR APPERGGAGT SQDGTSKNWF
   121  KITIPYGRKY DKAWLLSMIQ SKCSVPFTPI EFHYENTRAQ FFVEDASTAS ALKAVNYKIL
   181  DRENRRISII INSSAPPHTI LNELKPEQVE QLKLIMSKRY DGSQQALDLK GLRSDPDLVA
   241  QNIDVVLNRR SCMAATLRII EENIPELLSL NLSNNRLYRL DDMSSIVQKA PNLKILNLSG
   301  NELKSERELD KIKGLKLEEL WLDGNSLCDT FRDQSTYISA IRERFPKLLR LDGHELPPPI
   361  AFDVEAPTTL PPCKGSYFGT ENLKSLVLHF LQQYYAIYDS GDRQGLLDAY HDGACCSLSI
   421  PFIPQNPARS SLAEYFKDSR NVKKLKDPTL RFRLLKHTRL NVVAFLNELP KTQHDVNSFV
   481  VDISAQTSTL LCFSVNGVFK EVDGKSRDSL RAFTRTFIAV PASNSGLCIV NDELFVRNAS
   541  SEEIQRAFAM PAPTPSSSPV PTLSPEQQEM LQAFSTQSGM NLEWSQKCLQ DNNWDYTRSA
   601  QAFTHLKAKG EIPEVAFMK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NXF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
193 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 193 nTPM
  • spleen: 140 nTPM
  • pituitary gland: 134 nTPM
  • liver: 128 nTPM
  • thyroid gland: 121 nTPM
  • skin: 108 nTPM

Single-cell type

  • syncytiotrophoblasts: 153 nCPM
  • breast lactating cells: 122 nCPM
  • breast myoepithelial cells: 109 nCPM
  • tuft cells: 104 nCPM
  • cytotrophoblasts: 82 nCPM
  • neutrophil progenitors: 82 nCPM

Immune cell

  • intermediate monocyte: 26 nTPM
  • T-reg: 24 nTPM
  • non-classical monocyte: 24 nTPM
  • eosinophil: 24 nTPM
  • myeloid DC: 24 nTPM
  • classical monocyte: 21 nTPM

Brain region

  • choroid plexus: 63 nTPM
  • cerebellum: 51 nTPM
  • white matter: 47 nTPM
  • cerebral cortex: 46 nTPM
  • hypothalamus: 46 nTPM
  • thalamus: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.98
gnomAD missense Z
2.66
DepMap mean gene effect
-1.22
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NXF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NXF1 as an antibody target. Whether an autoantibody or antibody against NXF1 could matter depends on whether native NXF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NXF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NXF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NXF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...