Seroatlas · Human Serome Atlas

ENOX2

Ecto-NOX disulfide-thiol exchanger 2

Also known as: APK1, COVA1, ENOX2_HUMAN, tNOX

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16206
Gene
ENOX2
Ensembl
ENSG00000165675
Chromosome
X
Canonical length
610 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

610 residues, UniProt reviewed canonical sequence.

>Q16206|ENOX2
     1  MQRDFRWLWV YEIGYAADNS RTLNVDSTAM TLPMSDPTAW ATAMNNLGMA PLGIAGQPIL
    61  PDFDPALGMM TGIPPITPMM PGLGIVPPPI PPDMPVVKEI IHCKSCTLFP PNPNLPPPAT
   121  RERPPGCKTV FVGGLPENGT EQIIVEVFEQ CGEIIAIRKS KKNFCHIRFA EEYMVDKALY
   181  LSGYRIRLGS STDKKDTGRL HVDFAQARDD LYEWECKQRM LAREERHRRR MEEERLRPPS
   241  PPPVVHYSDH ECSIVAEKLK DDSKFSEAVQ TLLTWIERGE VNRRSANNFY SMIQSANSHV
   301  RRLVNEKAAH EKDMEEAKEK FKQALSGILI QFEQIVAVYH SASKQKAWDH FTKAQRKNIS
   361  VWCKQAEEIR NIHNDELMGI RREEEMEMSD DEIEEMTETK ETEESALVSQ AEALKEENDS
   421  LRWQLDAYRN EVELLKQEQG KVHREDDPNK EQQLKLLQQA LQGMQQHLLK VQEEYKKKEA
   481  ELEKLKDDKL QVEKMLENLK EKESCASRLC ASNQDSEYPL EKTMNSSPIK SEREALLVGI
   541  ISTFLHVHPF GASIEYICSY LHRLDNKICT SDVECLMGRL QHTFKQEMTG VGASLEKRWK
   601  FCGFEGLKLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENOX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
9.3 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 9.3 nTPM
  • tonsil: 8 nTPM
  • endometrium: 7.8 nTPM
  • thymus: 7.5 nTPM
  • tongue: 7.4 nTPM
  • lymph node: 7.3 nTPM

Single-cell type

  • sertoli cells: 189 nCPM
  • oligodendrocytes: 171 nCPM
  • salivary ionocytes: 151 nCPM
  • myonuclei: 149 nCPM
  • adrenal medulla cells: 149 nCPM
  • kupffer cells: 123 nCPM

Immune cell

  • intermediate monocyte: 14 nTPM
  • eosinophil: 13 nTPM
  • T-reg: 12 nTPM
  • naive B-cell: 12 nTPM
  • memory B-cell: 11 nTPM
  • naive CD4 T-cell: 11 nTPM

Brain region

  • basal ganglia: 17 nTPM
  • white matter: 17 nTPM
  • hypothalamus: 15 nTPM
  • thalamus: 14 nTPM
  • medulla oblongata: 14 nTPM
  • cerebral cortex: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
0.83
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENOX2 as an antibody target. Whether an autoantibody or antibody against ENOX2 could matter depends on whether native ENOX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENOX2 is annotated at the cell surface, where native ENOX2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ENOX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ENOX2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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