Seroatlas · Human Serome Atlas

HNRNPA3

Heterogeneous nuclear ribonucleoprotein A3

Also known as: HNRPA3, ROA3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51991
Gene: HNRNPA3
Ensembl: ENSG00000170144
Chromosome: 2
Canonical length: 378 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in nucleus. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

378 residues, UniProt reviewed canonical sequence.

>P51991|HNRNPA3
     1  MEVKPPPGRP QPDSGRRRRR RGEEGHDPKE PEQLRKLFIG GLSFETTDDS LREHFEKWGT
    61  LTDCVVMRDP QTKRSRGFGF VTYSCVEEVD AAMCARPHKV DGRVVEPKRA VSREDSVKPG
   121  AHLTVKKIFV GGIKEDTEEY NLRDYFEKYG KIETIEVMED RQSGKKRGFA FVTFDDHDTV
   181  DKIVVQKYHT INGHNCEVKK ALSKQEMQSA GSQRGRGGGS GNFMGRGGNF GGGGGNFGRG
   241  GNFGGRGGYG GGGGGSRGSY GGGDGGYNGF GGDGGNYGGG PGYSSRGGYG GGGPGYGNQG
   301  GGYGGGGGYD GYNEGGNFGG GNYGGGGNYN DFGNYSGQQQ SNYGPMKGGS FGGRSSGSPY
   361  GGGYGSGGGS GGYGSRRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HNRNPA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 294 nTPM

Expression across tissuesHPA

Tissue

thymus: 294 nTPM
tonsil: 290 nTPM
esophagus: 233 nTPM
lymph node: 218 nTPM
bone marrow: 214 nTPM
ovary: 201 nTPM

Single-cell type

erythrocyte progenitors: 508 nCPM
megakaryocyte progenitors: 437 nCPM
migrating cytotrophoblasts: 394 nCPM
extravillous trophoblasts: 390 nCPM
cytotrophoblasts: 368 nCPM
syncytiotrophoblasts: 358 nCPM

Immune cell

plasmacytoid DC: 44 nTPM
T-reg: 29 nTPM
gdT-cell: 29 nTPM
myeloid DC: 28 nTPM
intermediate monocyte: 27 nTPM
memory CD8 T-cell: 27 nTPM

Brain region

hypothalamus: 159 nTPM
medulla oblongata: 137 nTPM
cerebral cortex: 136 nTPM
thalamus: 131 nTPM
pons: 125 nTPM
cerebellum: 123 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 3.64
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

via spliceosome
mRNA splicing

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HNRNPA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HNRNPA3 as an antibody target. Whether an autoantibody or antibody against HNRNPA3 could matter depends on whether native HNRNPA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HNRNPA3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HNRNPA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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