Seroatlas · Human Serome Atlas

LARP4

La-related protein 4

Also known as: LARP4_HUMAN, PP13296

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q71RC2
Gene: LARP4
Ensembl: ENSG00000161813
Chromosome: 12
Canonical length: 724 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

Enables mRNA 3'-UTR binding activity and poly(A) binding activity. Involved in cytoskeleton organization; positive regulation of translation; and regulation of cell morphogenesis. Located in cytoplasmic stress granule and cytosolic small ribosomal subunit. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

724 residues, UniProt reviewed canonical sequence.

>Q71RC2|LARP4
     1  MLLFVEQVAS KGTGLNPNAK VWQEIAPGNT DATPVTHGTE SSWHEIAATS GAHPEGNAEL
    61  SEDICKEYEV MYSSSCETTR NTTGIEESTD GMILGPEDLS YQIYDVSGES NSAVSTEDLK
   121  ECLKKQLEFC FSRENLSKDL YLISQMDSDQ FIPIWTVANM EEIKKLTTDP DLILEVLRSS
   181  PMVQVDEKGE KVRPSHKRCI VILREIPETT PIEEVKGLFK SENCPKVISC EFAHNSNWYI
   241  TFQSDTDAQQ AFKYLREEVK TFQGKPIMAR IKAINTFFAK NGYRLMDSSI YSHPIQTQAQ
   301  YASPVFMQPV YNPHQQYSVY SIVPQSWSPN PTPYFETPLA PFPNGSFVNG FNSPGSYKTN
   361  AAAMNMGRPF QKNRVKPQFR SSGGSEHSTE GSVSLGDGQL NRYSSRNFPA ERHNPTVTGH
   421  QEQTYLQKET STLQVEQNGD YGRGRRTLFR GRRRREDDRI SRPHPSTAES KAPTPKFDLL
   481  ASNFPPLPGS SSRMPGELVL ENRMSDVVKG VYKEKDNEEL TISCPVPADE QTECTSAQQL
   541  NMSTSSPCAA ELTALSTTQQ EKDLIEDSSV QKDGLNQTTI PVSPPSTTKP SRASTASPCN
   601  NNINAATAVA LQEPRKLSYA EVCQKPPKEP SSVLVQPLRE LRSNVVSPTK NEDNGAPENS
   661  VEKPHEKPEA RASKDYSGFR GNIIPRGAAG KIREQRRQFS HRAIPQGVTR RNGKEQYVPP
   721  RSPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LARP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

liver: 57 nTPM
tongue: 34 nTPM
kidney: 27 nTPM
adrenal gland: 26 nTPM
skeletal muscle: 24 nTPM
parathyroid gland: 20 nTPM

Single-cell type

myonuclei: 349 nCPM
cardiomyocytes: 299 nCPM
choroid plexus epithelial cells: 251 nCPM
proximal tubule cells: 211 nCPM
renal collecting duct intercalated cells: 201 nCPM
hepatocytes: 201 nCPM

Immune cell

myeloid DC: 11 nTPM
non-classical monocyte: 11 nTPM
plasmacytoid DC: 9.8 nTPM
intermediate monocyte: 9 nTPM
naive B-cell: 8.4 nTPM
memory B-cell: 8.3 nTPM

Brain region

choroid plexus: 72 nTPM
white matter: 55 nTPM
cerebellum: 55 nTPM
midbrain: 53 nTPM
pons: 51 nTPM
medulla oblongata: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.87
gnomAD missense Z: 0.99
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LARP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LARP4 as an antibody target. Whether an autoantibody or antibody against LARP4 could matter depends on whether native LARP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LARP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LARP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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