RBMXL2

Protein identityUniProt · HPA

UniProt accession

O75526

Gene

RBMXL2

Ensembl

ENSG00000170748

Chromosome

11

Canonical length

392 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind RNAs. This gene is intronless and is thought to be derived from a processed retroposon. However, unlike many retroposon-derived genes, this gene is not a pseudogene. The encoded protein has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

392 residues, UniProt reviewed canonical sequence.

>O75526|RBMXL2
     1  MVEADRPGKL FIGGLNLETD EKALEAEFGK YGRIVEVLLM KDRETNKSRG FAFVTFESPA
    61  DAKAAARDMN GKSLDGKAIK VAQATKPAFE SSRRGPPPPR SRGRPRFLRG TRGGGGGPRR
   121  SPSRGGPDDD GGYTADFDLR PSRAPMPMKR GPPPRRVGPP PKRAAPSGPA RSSGGGMRGR
   181  ALAVRGRDGY SGPPRREPLP PRRDPYLGPR DEGYSSRDGY SSRDYREPRG FAPSPGEYTH
   241  RDYGHSSVRD DCPLRGYSDR DGYGGRDRDY GDHLSRGSHR EPFESYGELR GAAPGRGTPP
   301  SYGGGGRYEE YRGYSPDAYS GGRDSYSSSY GRSDRYSRGR HRVGRPDRGL SLSMERGCPP
   361  QRDSYSRSGC RVPRGGGRLG GRLERGGGRS RY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBMXL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.66

Highest tissue expression

29 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.73

gnomAD pLI

0.07

gnomAD missense Z

0.24

DepMap mean gene effect

0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• via spliceosome
• mRNA splicing

Molecular functions

• mRNA binding
• snRNA binding

Cellular components

• nucleus
• ribonucleoprotein complex

Protein domainsUniProt · Pfam · InterPro

• RNA recognition motif domain
• RNA recognition motif domain, eukaryotic-type
• RBM1CTR
• Nucleotide-binding alpha-beta plait domain superfamily
• RNA-binding domain superfamily
• RNA-binding motif
• RNA recognition motif
• RBM1CTR (NUC064) family

KeywordsUniProt

• Nucleus
• Ribonucleoprotein
• RNA-binding