Seroatlas · Protein domains

Winged helix-like DNA-binding domain superfamily

IPR036388

Definition

Winged helix DNA-binding proteins share a related winged helix-turn-helix DNA-binding motif, where the "wings", or loops, are small β-sheets. The winged helix motif consists of two wings (W1, W2), three α-helices (H1, H2, H3) and three β-sheets (S1, S2, S3) arranged in the order H1-S1-H2-H3-S2-W1-S3-W2 PMID:10679470. The DNA-recognition helix makes sequence-specific DNA contacts with the major groove of DNA, while the wings make different DNA contacts, often with the minor groove or the backbone of DNA. Several winged-helix proteins display an exposed patch of hydrophobic residues thought to mediate protein-protein interactions. Many different proteins with diverse biological functions contain a winged helix DNA-binding domain, including transcriptional repressors such as biotin repressor, LexA repressor and the arginine repressor PMID:1409631; transcription factors such as the hepatocyte nuclear factor-3 proteins involved in cell differentiation, heat-shock transcription factor, and the general transcription factors TFIIE and TFIIF [[cite:PMID:8248124], [cite:PMID:11292844]]; helicases such as RuvB that promotes branch migration at the Holliday junction, and CDC6 in the pre-replication complex [[cite:PMID:12408833], [cite:PMID:11030343]]; endonucleases such as FokI and TnsA PMID:9214510; histones; and Mu transposase, where the flexible wing of the enhancer-binding domain is essential for efficient transposition PMID:8577730.

239 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (239 proteins: gene, accession, name)

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