Seroatlas · Human Serome Atlas

CUL5

Cullin-5

Also known as: CUL5_HUMAN, VACM-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q93034
Gene
CUL5
Ensembl
ENSG00000166266
Chromosome
11
Canonical length
780 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein K11-linked ubiquitination. Located in site of DNA damage. Part of Cul5-RING ubiquitin ligase complex. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

780 residues, UniProt reviewed canonical sequence.

>Q93034|CUL5
     1  MATSNLLKNK GSLQFEDKWD FMRPIVLKLL RQESVTKQQW FDLFSDVHAV CLWDDKGPAK
    61  IHQALKEDIL EFIKQAQARV LSHQDDTALL KAYIVEWRKF FTQCDILPKP FCQLEITLMG
   121  KQGSNKKSNV EDSIVRKLML DTWNESIFSN IKNRLQDSAM KLVHAERLGE AFDSQLVIGV
   181  RESYVNLCSN PEDKLQIYRD NFEKAYLDST ERFYRTQAPS YLQQNGVQNY MKYADAKLKE
   241  EEKRALRYLE TRRECNSVEA LMECCVNALV TSFKETILAE CQGMIKRNET EKLHLMFSLM
   301  DKVPNGIEPM LKDLEEHIIS AGLADMVAAA ETITTDSEKY VEQLLTLFNR FSKLVKEAFQ
   361  DDPRFLTARD KAYKAVVNDA TIFKLELPLK QKGVGLKTQP ESKCPELLAN YCDMLLRKTP
   421  LSKKLTSEEI EAKLKEVLLV LKYVQNKDVF MRYHKAHLTR RLILDISADS EIEENMVEWL
   481  REVGMPADYV NKLARMFQDI KVSEDLNQAF KEMHKNNKLA LPADSVNIKI LNAGAWSRSS
   541  EKVFVSLPTE LEDLIPEVEE FYKKNHSGRK LHWHHLMSNG IITFKNEVGQ YDLEVTTFQL
   601  AVLFAWNQRP REKISFENLK LATELPDAEL RRTLWSLVAF PKLKRQVLLY EPQVNSPKDF
   661  TEGTLFSVNQ EFSLIKNAKV QKRGKINLIG RLQLTTERMR EEENEGIVQL RILRTQEAII
   721  QIMKMRKKIS NAQLQTELVE ILKNMFLPQK KMIKEQIEWL IEHKYIRRDE SDINTFIYMA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CUL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
43 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 43 nTPM
  • tongue: 35 nTPM
  • bone marrow: 27 nTPM
  • kidney: 15 nTPM
  • heart muscle: 14 nTPM
  • thyroid gland: 14 nTPM

Single-cell type

  • renal collecting duct intercalated cells: 315 nCPM
  • myonuclei: 296 nCPM
  • rod photoreceptor cells: 186 nCPM
  • pituicytes/fscs: 184 nCPM
  • distal convoluted tubule cells: 172 nCPM
  • neutrophil progenitors: 164 nCPM

Immune cell

  • plasmacytoid DC: 2.5 nTPM
  • naive CD8 T-cell: 2.4 nTPM
  • classical monocyte: 2.3 nTPM
  • myeloid DC: 2.3 nTPM
  • naive CD4 T-cell: 2.3 nTPM
  • naive B-cell: 2.2 nTPM

Brain region

  • cerebellum: 25 nTPM
  • white matter: 23 nTPM
  • cerebral cortex: 21 nTPM
  • hypothalamus: 19 nTPM
  • spinal cord: 18 nTPM
  • choroid plexus: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CUL5.

Disease | ImmuneIEDB

Conditions an epitope on CUL5 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.16
gnomAD pLI
1
gnomAD missense Z
4.59
DepMap mean gene effect
0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CUL5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CUL5 as an antibody target. Whether an autoantibody or antibody against CUL5 could matter depends on whether native CUL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CUL5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CUL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CUL5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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