DEPDC4
DEP domain-containing protein 4
Also known as: DEP.4, DEPD4_HUMAN, FLJ33505
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N2C3
- Gene
- DEPDC4
- Ensembl
- ENSG00000166153
- Chromosome
- 12
- Canonical length
- 294 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Microtubules
OverviewNCBI Gene
Predicted to be involved in intracellular signal transduction. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
294 residues, UniProt reviewed canonical sequence.
>Q8N2C3|DEPDC4
1 MVPGEEPARE LMAVLLTPRF RRLVSQNELP GPGLNGPSSR NRRDGFCRKR RTGCSGPFQA
61 TQLWDGIIHS LQAQVEIKRR RHHLQTYKDC FTGSDAVDVV LSHLMQNTCL SSNDISCLKG
121 VHLCQVLMNH KVFEPVGMKK LFKKEKELEF EDSNISLYRF LGNKSSYDCC KRQKDAENEF
181 NETLRPGYEM ISNPLAQEIG EERIEELIHT INGNPALCPN ITVQKPFLRL SKEDVWKEQT
241 LLCLLQLIHL PFLDNILEPP VKTQNLQLNK EEDLVITNTC LDRELIPSLC LPEKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DEPDC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 2.9 nTPM
Expression across tissuesHPA
Tissue
- testis: 2.9 nTPM
- kidney: 1.7 nTPM
- liver: 1.4 nTPM
- duodenum: 1.1 nTPM
- seminal vesicle: 1 nTPM
- breast: 0.9 nTPM
Single-cell type
- epicardial cells: 41 nCPM
- cardiomyocytes: 38 nCPM
- late spermatids: 31 nCPM
- adipocytes: 26 nCPM
- late primary spermatocytes: 24 nCPM
- sertoli cells: 23 nCPM
Immune cell
- naive B-cell: 1 nTPM
- basophil: 0.8 nTPM
- neutrophil: 0.6 nTPM
- naive CD4 T-cell: 0.5 nTPM
- naive CD8 T-cell: 0.3 nTPM
- classical monocyte: 0.1 nTPM
Brain region
- white matter: 4 nTPM
- hypothalamus: 3.9 nTPM
- cerebral cortex: 3.6 nTPM
- amygdala: 3.3 nTPM
- pons: 3.1 nTPM
- basal ganglia: 3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.73
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.34
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DEPDC4 as an antibody target. Whether an autoantibody or antibody against DEPDC4 could matter depends on whether native DEPDC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DEPDC4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DEPDC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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